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Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects, which is an expected issue in clinical. In this work, 3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite (HA) coating via a hydrothermal treatment, achieving the functions of photothermal-induced antibacterial ability and bioactivity. The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro, owing to the photothermal effect of free carbon embedded in the scaffolds. The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment. Furthermore, HA coating did not influence the mechanical strength and photothermal effect of the scaffolds, but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) on scaffolds. Hence, the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.


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Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

Show Author's information Weiye LIUa,bRongtai ZUOcTanglong ZHUa,bMin ZHUa( )Shichang ZHAOc( )Yufang ZHUb( )
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Department of Orthopedics, Shanghai Jiao Tong University affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

† Weiye Liu and Rongtai Zuo contributed equally to this work.

Abstract

Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects, which is an expected issue in clinical. In this work, 3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite (HA) coating via a hydrothermal treatment, achieving the functions of photothermal-induced antibacterial ability and bioactivity. The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro, owing to the photothermal effect of free carbon embedded in the scaffolds. The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment. Furthermore, HA coating did not influence the mechanical strength and photothermal effect of the scaffolds, but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) on scaffolds. Hence, the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.

Keywords:

forsterite scaffolds, hydroxyapatite (HA) coating, bone repair, photothermal effect, antibacterial activity
Received: 26 December 2020 Revised: 16 March 2021 Accepted: 05 May 2021 Published: 20 September 2021 Issue date: October 2021
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Publication history
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Publication history

Received: 26 December 2020
Revised: 16 March 2021
Accepted: 05 May 2021
Published: 20 September 2021
Issue date: October 2021

Copyright

© The Author(s) 2021

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51872185, 51972212, and 52072246) and Shanghai Natural Science Foundation (No. 19ZR1435100).

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