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Journal of Advanced Ceramics 2021, 10(5): 1095-1106 https://doi.org/10.1007/s40145-021-0494-x
Research Article | Open Access | Issue | Published: 20 September 2021

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

Show Author's Information Weiye LIUa,b,†,  Rongtai ZUOc,†,  Tanglong ZHUa,b,  Min ZHUa( ),  Shichang ZHAOc( ),  Yufang ZHUb( )
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Department of Orthopedics, Shanghai Jiao Tong University affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

† Weiye Liu and Rongtai Zuo contributed equally to this work.

Keywords:
forsterite scaffolds, hydroxyapatite (HA) coating, bone repair, photothermal effect, antibacterial activity
Cite this article:
LIU W, ZUO R, ZHU T, et al. Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair. Journal of Advanced Ceramics, 2021, 10(5): 1095-1106. https://doi.org/10.1007/s40145-021-0494-x
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Abstract Full text About this article

Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects, which is an expected issue in clinical. In this work, 3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite (HA) coating via a hydrothermal treatment, achieving the functions of photothermal-induced antibacterial ability and bioactivity. The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro, owing to the photothermal effect of free carbon embedded in the scaffolds. The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment. Furthermore, HA coating did not influence the mechanical strength and photothermal effect of the scaffolds, but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) on scaffolds. Hence, the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.


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About this article

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

Show Author's information Weiye LIUa,b,†, Rongtai ZUOc,†, Tanglong ZHUa,b, Min ZHUa( ), Shichang ZHAOc( ), Yufang ZHUb( )
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Department of Orthopedics, Shanghai Jiao Tong University affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

† Weiye Liu and Rongtai Zuo contributed equally to this work.

Abstract

Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects, which is an expected issue in clinical. In this work, 3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite (HA) coating via a hydrothermal treatment, achieving the functions of photothermal-induced antibacterial ability and bioactivity. The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro, owing to the photothermal effect of free carbon embedded in the scaffolds. The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment. Furthermore, HA coating did not influence the mechanical strength and photothermal effect of the scaffolds, but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) on scaffolds. Hence, the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.

Keywords: forsterite scaffolds, hydroxyapatite (HA) coating, bone repair, photothermal effect, antibacterial activity

References(34)

[1]
Turnbull G, Clarke J, Picard F, et al. 3D bioactive composite scaffolds for bone tissue engineering. Bioact Mater 2018, 3: 278-314.
DOI Google Scholar
[2]
Alonzo M, Alvarez P F, Anil K S, et al. Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects. Curr Opin Biomed Eng 2021, 17: 100248.
DOI Google Scholar
[3]
Pei P, Wei DX, Zhu M, et al. The effect of calcium sulfate incorporation on physiochemical and biological properties of 3D-printed mesoporous calcium silicate cement scaffolds. Microporous Mesoporous Mater 2017, 241: 11-20.
DOI Google Scholar
[4]
Myat-Htun M, Mohd Noor AF, Kawashita M, et al. Enhanced sinterability and in vitro bioactivity of barium- doped akermanite ceramic. Ceram Int 2020, 46: 19062-19068.
DOI Google Scholar
[5]
Keihan R, Ghorbani AR, Salahinejad E, et al. Biomineralization, strength and cytocompatibility improvement of bredigite scaffolds through doping/coating. Ceram Int 2020, 46: 21056-21063.
DOI Google Scholar
[6]
Jones JR. Review of bioactive glass: From Hench to hybrids. Acta Biomater 2013, 9: 4457-4486.
DOI Google Scholar
[7]
Ramesh S, Yaghoubi A, Lee KYS, et al. Nanocrystalline forsterite for biomedical applications: Synthesis, microstructure and mechanical properties. J Mech Behav Biomed Mater 2013, 25: 63-69.
DOI Google Scholar
[8]
Choudhary R, Chatterjee A, Venkatraman SK, et al. Antibacterial forsterite (Mg2SiO4) scaffold: A promising bioceramic for load bearing applications. Bioact Mater 2018, 3: 218-224.
DOI Google Scholar
[9]
Krishnamurithy G, Mohan S, Yahya NA, et al. The physicochemical and biomechanical profile of forsterite and its osteogenic potential of mesenchymal stromal cells. PLoS One 2019, 14: e0214212.
DOI Google Scholar
[10]
Tavangarian F, Fahami A, Li GQ, et al. Structural characterization and strengthening mechanism of forsterite nanostructured scaffolds synthesized by multistep sintering method. J Mater Sci Technol 2018, 34: 2263-2270.
DOI Google Scholar
[11]
Fu SY, Zhu M, Zhu YF. Organosilicon polymer-derived ceramics: An overview. J Adv Ceram 2019, 8: 457-478.
DOI Google Scholar
[12]
Zhu TL, Zhu M, Zhu YF. Fabrication of forsterite scaffolds with photothermal-induced antibacterial activity by 3D printing and polymer-derived ceramics strategy. Ceram Int 2020, 46: 13607-13614.
DOI Google Scholar
[13]
Fu SY, Hu HR, Chen JJ, et al. Silicone resin derived larnite/C scaffolds via 3D printing for potential tumor therapy and bone regeneration. Chem Eng J 2020, 382: 122928.
DOI Google Scholar
[14]
Tavangarian F, Emadi R. Improving degradation rate and apatite formation ability of nanostructure forsterite. Ceram Int 2011, 37: 2275-2280.
DOI Google Scholar
[15]
Saidi R, Fathi M, Salimijazi H. Synthesis and characterization of bioactive glass coated forsterite scaffold for tissue engineering applications. J Alloys Compd 2017, 727: 956-962.
DOI Google Scholar
[16]
Naghieh S, Foroozmehr E, Badrossamay M, et al. Combinational processing of 3D printing and electrospinning of hierarchical poly(lactic acid)/gelatin-forsterite scaffolds as a biocomposite: Mechanical and biological assessment. Mater Des 2017, 133: 128-135.
DOI Google Scholar
[17]
Lim HK, Byun SH, Lee JY, et al. Radiological, histological, and hematological evaluation of hydroxyapatite-coated resorbable magnesium alloy screws placed in rabbit tibia. J Biomed Mater Res B: Appl Biomater 2017, 105: 1636-1644.
DOI Google Scholar
[18]
Wen ZH, Zhang LM, Chen C, et al. A construction of novel iron-foam-based calcium phosphate/chitosan coating biodegradable scaffold material. Mater Sci Eng C Mater Biol Appl 2013, 33: 1022-1031.
DOI Google Scholar
[19]
Huan YC, Wu KD, Li CJ, et al. Micro-nano structured functional coatings deposited by liquid plasma spraying. J Adv Ceram 2020, 9: 517-534.
DOI Google Scholar
[20]
Um SH, Chung YW, Seo Y, et al. Robust hydroxyapatite coating by laser-induced hydrothermal synthesis. Adv Funct Mater 2020, 30: 2005233.
DOI Google Scholar
[21]
Ripamonti U, Crooks J, Khoali L, et al. The induction of bone formation by coral-derived calcium carbonate/ hydroxyapatite constructs. Biomaterials 2009, 30: 1428-1439.
DOI Google Scholar
[22]
Liu HR, Xia LL, Dai Y, et al. Fabrication and characterization of novel hydroxyapatite/porous carbon composite scaffolds. Mater Lett 2012, 66: 36-38.
DOI Google Scholar
[23]
Liu JB, Ye XY, Wang H, et al. The influence of pH and temperature on the morphology of hydroxyapatite synthesized by hydrothermal method. Ceram Int 2003, 29: 629-633.
DOI Google Scholar
[24]
Chen HF, Tang ZY, Liu J, et al. Acellular synthesis of a human enamel-like microstructure. Adv Mater 2006, 18: 1846-1851.
DOI Google Scholar
[25]
Zhang CM, Yang J, Quan ZW, et al. Hydroxyapatite nano- and micro-crystals with multiform morphologies: Controllable synthesis and luminescence properties. Cryst Growth Des 2009, 9: 2725-2733.
DOI Google Scholar
[26]
Chen W, Long T, Guo YJ, et al. Magnetic hydroxyapatite coatings with oriented nanorod arrays: Hydrothermal synthesis, structure and biocompatibility. J Mater Chem B 2014, 2: 1653.
DOI Google Scholar
[27]
Yang C, Huan ZG, Wang XY, et al. 3D printed Fe scaffolds with HA nanocoating for bone regeneration. ACS Biomater Sci Eng 2018, 4: 608-616.
DOI Google Scholar
[28]
Hu JZ, Zhou YC, Huang LH, et al. Effect of nano-hydroxyapatite coating on the osteoinductivity of porous biphasic calcium phosphate ceramics. BMC Musculoskelet Disord 2014, 15: 114.
DOI Google Scholar
[29]
Gloria A, Russo T, D'Amora U, et al. Magnetic poly(ε-caprolactone)/iron-doped hydroxyapatite nanocomposite substrates for advanced bone tissue engineering. J R Soc Interface 2013, 10: 20120833.
DOI Google Scholar
[30]
Yang JC, Zhang J, Ding C, et al. Regulation of osteoblast differentiation and iron content in MC3T3-E1 cells by static magnetic field with different intensities. Biol Trace Elem Res 2018, 184: 214-225.
DOI Google Scholar
[31]
Wiedmer D, Cui C, Weber F, et al. Antibacterial surface coating for bone scaffolds based on the dark catalytic effect of titanium dioxide. ACS Appl Mater Interfaces 2018, 10: 35784-35793.
DOI Google Scholar
[32]
In Y, Amornkitbamrung U, Hong MH, et al. On the crystallization of hydroxyapatite under hydrothermal conditions: Role of sebacic acid as an additive. ACS Omega 2020, 5: 27204-27210.
DOI Google Scholar
[33]
Cui BC, Zhang RR, Sun FB, et al. Mechanical and biocompatible properties of polymer-infiltrated-ceramic- network materials for dental restoration. J Adv Ceram 2020, 9: 123-128.
DOI Google Scholar
[34]
Yang C, Wang XY, Ma B, et al. 3D-printed bioactive Ca3SiO5 bone cement scaffolds with nano surface structure for bone regeneration. ACS Appl Mater Interfaces 2017, 9: 5757-5767.
DOI Google Scholar
Publication history
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Publication history

Received: 26 December 2020
Revised: 16 March 2021
Accepted: 05 May 2021
Published: 20 September 2021
Issue date: October 2021

Copyright

© The Author(s) 2021

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51872185, 51972212, and 52072246) and Shanghai Natural Science Foundation (No. 19ZR1435100).

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