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It has well known that hydroxyapatite (HA) is a kind of excellent materials for biomolecular absorption and separation, and the absorption and separation performances of HA would be improved if HA had been processed into desirable porous structures. In this paper, we reported on the combination of gel casting and freeze casting to develop the through-porous hydroxyapatite ceramic monoliths. Experiments demonstrated that the gel-containing freeze casting technique was an isotropic pore-forming technique and could prepare the near-net-shape forming green bodies with good mechanical strength no matter what the HA content in green bodies was. Further green body sintering formed the through-porous ceramics whose grain size, pore size, and porosity depended on and could be controlled by the content of HA in green bodies. The formation of through-pores in ceramics resulted from the gels and water in green bodies, which acted as the templates of the pores with size < 1 µm and the pores with size > 1 µm, respectively. The gel-freeze casting technique is simple, repeatable, and cost-effective, therefore being hopeful for industrial applications.


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Isotropic freeze casting of through-porous hydroxyapatite ceramics

Show Author's information Zhen WUZhengren ZHOUYouliang HONG( )
National Engineering Center for Biomaterials, Sichuan University, Chengdu 610064, China

Abstract

It has well known that hydroxyapatite (HA) is a kind of excellent materials for biomolecular absorption and separation, and the absorption and separation performances of HA would be improved if HA had been processed into desirable porous structures. In this paper, we reported on the combination of gel casting and freeze casting to develop the through-porous hydroxyapatite ceramic monoliths. Experiments demonstrated that the gel-containing freeze casting technique was an isotropic pore-forming technique and could prepare the near-net-shape forming green bodies with good mechanical strength no matter what the HA content in green bodies was. Further green body sintering formed the through-porous ceramics whose grain size, pore size, and porosity depended on and could be controlled by the content of HA in green bodies. The formation of through-pores in ceramics resulted from the gels and water in green bodies, which acted as the templates of the pores with size < 1 µm and the pores with size > 1 µm, respectively. The gel-freeze casting technique is simple, repeatable, and cost-effective, therefore being hopeful for industrial applications.

Keywords: ceramics, hydroxyapatite (HA), gel-freeze casting, through-pores, near-net-shape

References(27)

[1]
Y Chen, ZH Sun, YY Li, et al. Preparation and biological effects of apatite nanosheet-constructed porous ceramics. J Mater Chem B 2017, 5: 807-816.
[2]
Y Yamasaki, A Yokoyama, A Ohnaka, et al. High-performance hydroxyapatite chromatography of nucleic acids. J Chromatogr 1989, 467: 299-303.
[3]
HR Low, M Avdeev, K Ramesh, et al. Zinc hydroxyapatite catalyst for decomposition of 2-propanol. Adv Mater 2012, 24: 4175-4179.
[4]
RU Mene, MP Mahabole, R Sharma, et al. Enhancement in CO gas sensing properties of hydroxyapatite thick films: Effect of swift heavy ion irradiation. Vacuum 2011, 86: 66-71.
[5]
SD Jiang, QZ Yao, GT Zhou, et al. Fabrication of hydroxyapatite hierarchical hollow microspheres and potential application in water treatment. J Phys Chem C 2012, 116: 4484-4492.
[6]
N Tanaka, H Kobayashi, K Nakanishi, et al. A new type of chromatographic support could lead to higher separation efficiencies. Anal Chem 2001, 73: 420A-429A.
[7]
M Descamps, O Richart, P Hardouin, et al. Synthesis of macroporous β-tricalcium phosphate with controlled porous architectural. Ceram Int 2008, 34: 1131-1137.
[8]
B Liu, PH Lin, Y Shen, et al. Porous bioceramics reinforced by coating gelatin. J Mater Sci: Mater Med 2008, 19: 1203-1207.
[9]
YL Hong, HS Fan, B Li, et al. Fabrication, biological effects, and medical applications of calcium phosphate nanoceramics. Mater Sci Eng R Rep 2010, 70: 225-242.
[10]
S Deville, E Saiz, RK Nalla, et al. Freezing as a path to build complex composites. Science 2006, 311: 515-518.
[11]
M Descamps, T Duhoo, F Monchau, et al. Manufacture of macroporous β-tricalcium phosphate bioceramics. J Eur Ceram Soc 2008, 28: 149-157.
[12]
NO Engin, AC Tas. Manufacture of macroporous calcium hydroxyapatite bioceramics. J Eur Ceram Soc 1999, 19: 2569-2572.
[13]
Q Fu, MN Rahaman, F Dogan, et al. Freeze casting of porous hydroxyapatite scaffolds. I. Processing and general microstructure. J Biomed Mater Res 2008, 86B: 125-135.
[14]
JS Reed. Critical issues and future directions in powder forming processes. In: Ceramic Transactions, Vol. 1, Ceramic Powder Science I1 (B). GL Messing, ER Fuller Jr., H Hausner, Eds. American Ceramic Society, 1987: 601-610.
[15]
PDS St Pierre. Slip casting nonclay ceramics. In: Ceramic Fabrication Processes. WD Kingery, Ed. MIT Press, 1963: 45-51.
[16]
JA Mangels. Injection molding ceramics. In: Proceedings of the 6th Annual Conference on Composites and Advanced Ceramic Materials: Ceramic Engineering and Science Proceedings, 2008.
[17]
AC Young, OO Omatete, MA Janney, et al. Gelcasting of alumina. J Am Ceram Soc 1991, 74: 612-618.
[18]
OO Omatete, MA Janney, SD Nunn. Gelcasting: From laboratory development toward industrial production. J Eur Ceram Soc 1997, 17: 407-413.
[19]
P Sepulveda, FS Ortega, MDM Innocentini, et al. Properties of highly porous hydroxyapatite obtained by the gelcasting of foams. J Am Ceram Soc 2000, 83: 3021-3024.
[20]
HR Ramay, MQ Zhang. Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods. Biomaterials 2003, 24: 3293-3302.
[21]
S Raynaud, E Champion, D Bernache-Assollant, et al. Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders. Biomaterials 2002, 23: 1065-1072.
[22]
S Padilla, R Garcı́a-Carrodeguas, M Vallet-Regı́. Hydroxyapatite suspensions as precursors of pieces obtained by gelcasting method. J Eur Ceram Soc 2004, 24: 2223-2232.
[23]
FS Ortega, P Sepulveda, VC Pandolfelli. Monomer systems for the gelcasting of foams. J Eur Ceram Soc 2002, 22: 1395-1401.
[24]
S Deville, E Saiz, AP Tomsia. Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. Biomaterials 2006, 27: 5480-5489.
[25]
KL Scotti, DC Dunand. Freeze casting—A review of processing, microstructure and properties via the open data repository, FreezeCasting.net. Prog Mater Sci 2018, 94: 243-305.
[26]
D Munz, T Fett. Ceramics: Mchanical Properties, Failure Behaviour, Materials, Selection. Springer, 1999.
DOI
[27]
MA Mattoni, JY Yang, CG Levi, et al. Effects of matrix porosity on the mechanical properties of a porous-matrix, all-oxide ceramic composite. J Am Ceram Soc 2001, 84: 2594-2602.
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Publication history

Received: 22 August 2018
Revised: 11 December 2018
Accepted: 14 December 2018
Published: 13 June 2019
Issue date: June 2019

Copyright

© The author(s) 2019

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 31570977).

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