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Journal of Advanced Ceramics 2016, 5(1): 47-53 https://doi.org/10.1007/s40145-015-0172-y
Research Article | Open Access | Issue | Published: 07 January 2016

Bioactivity of quaternary glass prepared from bentonite clay

Show Author's Information Luqman A. ADAMSa( ),  Enobong R. ESSIENb
Department of Chemistry, University of Lagos, Nigeria
Department of Chemical Sciences, Bells University of Technology, P.M.B 1015 Ota, Ogun, Nigeria
Keywords:
bentonite clay, bioactivity, alkoxysilane, hydroxyapatite (HA), bone repair
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ADAMS LA, ESSIEN ER. Bioactivity of quaternary glass prepared from bentonite clay. Journal of Advanced Ceramics, 2016, 5(1): 47-53. https://doi.org/10.1007/s40145-015-0172-y
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Abstract Full text About this article

Alkoxysilane precursors are the most widely used silica source for sol–gel preparation of silicate-based bioactive glass. However, due to their high cost, alternative sources such as bentonite clay are desirable. In the present work, bentonite clay was reacted with sodium hydroxide (NaOH) to extract sodium metasilicate (Na2SiO3). The obtained Na2SiO3 was converted to gel which was then sintered at 950 ℃ for 3 h to give the bioactive glass in the quaternary composition SiO2–NaO–CaO– P2O5. The resulting glass was incubated in simulated body fluid (SBF) for 0–7 days to evaluate the bioactivity. Furthermore, glass samples were characterized before and after SBF study by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Results obtained showed the presence of Na2Ca2Si3O9 (combeite) crystal as the major crystalline phase and the formation of hydroxyapatite (HA) and hydroxycarbonated apatite (HCA) on the surface of the glass after immersion in SBF. The material showed potentials for application as scaffold in bone tissue repair.


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About this article

Bioactivity of quaternary glass prepared from bentonite clay

Show Author's information Luqman A. ADAMSa( ), Enobong R. ESSIENb
Department of Chemistry, University of Lagos, Nigeria
Department of Chemical Sciences, Bells University of Technology, P.M.B 1015 Ota, Ogun, Nigeria

Abstract

Alkoxysilane precursors are the most widely used silica source for sol–gel preparation of silicate-based bioactive glass. However, due to their high cost, alternative sources such as bentonite clay are desirable. In the present work, bentonite clay was reacted with sodium hydroxide (NaOH) to extract sodium metasilicate (Na2SiO3). The obtained Na2SiO3 was converted to gel which was then sintered at 950 ℃ for 3 h to give the bioactive glass in the quaternary composition SiO2–NaO–CaO– P2O5. The resulting glass was incubated in simulated body fluid (SBF) for 0–7 days to evaluate the bioactivity. Furthermore, glass samples were characterized before and after SBF study by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Results obtained showed the presence of Na2Ca2Si3O9 (combeite) crystal as the major crystalline phase and the formation of hydroxyapatite (HA) and hydroxycarbonated apatite (HCA) on the surface of the glass after immersion in SBF. The material showed potentials for application as scaffold in bone tissue repair.

Keywords: bentonite clay, bioactivity, alkoxysilane, hydroxyapatite (HA), bone repair

References(38)

[1]
Lee S-C, Chen J-F, Wu C-T, et al. In situ local autograft for instrumented lower lumbar or lumbosacral posterolateral fusion. J Clin Neurosci 2009, 16: 37–43.
DOI Google Scholar
[2]
Damien CJ, Parsons JP. Bone graft and bone substitutes: A review of current technology and applications. J Appl Biomater 1991, 2: 187–208.
DOI Google Scholar
[3]
Calori GM, Mazza E, Colombo M, et al. The use of bone-graft substitutes in large bone defects: Any specific needs? Injury 2011, 42: S56–S63.
DOI Google Scholar
[4]
Rose FRAJ, Oreffo ROC. Bone tissue engineering: Hope vs hype. Biochem Bioph Res Co 2002, 292: 1–7.
DOI Google Scholar
[5]
Hench LL. Bioceramics. J Am Ceram Soc 1998, 81: 1705–1728.
DOI Google Scholar
[6]
Rahaman MN, Day DE, Bal BS, et al. Bioactive glass in tissue engineering. Acta Biomater 2011, 7: 2355–2373.
DOI Google Scholar
[7]
Oonishi H, Hench LL, Wilson J, et al. Comparative bone growth behaviour in granules of bioceramic materials of various sizes. J Biomed Mater Res 1999, 44: 31–43.
DOI
[8]
Olmo N, Martin AI, Salinas AJ, et al. Bioactive sol–gel glasses with and without a hydroxycarbonate apatite layer as substrates for osteoblast cell adhesion and proliferation. Biomaterials 2003, 24: 3383–3393.
DOI Google Scholar
[9]
Jell G, Stevens MM. Gene activation by bioactive glasses. J Mater Sci: Mater M 2006, 17: 997–1002.
DOI Google Scholar
[10]
Pereira MM, Jones JR, Orefice RL, et al. Preparation of bioactive glass-polyvinyl alcohol hybrid foams by the sol–gel method. J Mater Sci: Mater M 2005, 16: 1045–1050.
DOI Google Scholar
[11]
Wu C, Luo Y, Cuniberti G, et al. Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater 2011, 7: 2644–2650.
DOI Google Scholar
[12]
Fardad MA. Catalysis and structure of SiO2 sol–gel films. J Mater Sci 2000, 35: 1835–1841.
DOI Google Scholar
[13]
Essien ER, Adams LA, Shaibu, RO, et al. Economic route to sodium-containing silicate bioactive glass scaffold. Open Journal of Regenerative Medicine 2012, 1: 33–40.
DOI Google Scholar
[14]
Essien ER, Adams LA, Shaibu, RO, et al. Sol–gel bioceramic material from bentonite clay. Journal of Biomedical Science and Engineering 2013, 6: 258–264.
DOI Google Scholar
[15]
Essien ER, Olaniyi OA, Adams LA, et al. Sol–gel-derived porous silica: Economic synthesis and characterization. Journal of Minerals and Materials Characterization and Engineering 2012, 11: 976–981.
DOI Google Scholar
[16]
Cao W, Hench LL. Bioactive materials. Ceram Int 1996, 22: 493–507.
DOI Google Scholar
[17]
Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 2006, 27: 2907–2915.
DOI Google Scholar
[18]
Clupper DC, Mecholsky Jr. JJ, LaTorre GP, et al. Sintering temperature effects on the in vitro bioactive response of tape cast and sintered bioactive glass-ceramic in Tris buffer. J Biomed Mater Res 2001, 57: 532–540.
DOI
[19]
Clupper DC, Mecholsky Jr. JJ, LaTorre GP, et al. Bioactivity of tape cast and sintered bioactive glass-ceramic in simulated body fluid. Biomaterials 2002, 23: 2599–2606.
DOI Google Scholar
[20]
Chen Q-Z, Li Y, Jin L-Y, et al. A new sol–gel process for producing Na2O-containing bioactive glass ceramics. Acta Biomater 2010, 6: 4143–4153.
DOI Google Scholar
[21]
Gerhardt L-C, Boccaccini AR. Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials 2010, 3: 3867–3910.
DOI Google Scholar
[22]
Peitl O, Zanotto ED, Hench LL. Highly bioactive P2O5–Na2O–CaO–SiO2 glass-ceramics. J Non-Cryst Solids 2001, 292: 115–126.
DOI Google Scholar
[23]
Oliveira JM, Correia RN, Fernandes MH. Effects of Si speciation on the in vitro bioactivity of glasses. Biomaterials 2002, 23: 371–379.
DOI Google Scholar
[24]
Alexandre M, Dubois P. Polymer-layered silicate nanocomposites: Preparation, properties and uses of a new class of materials. Mat Sci Eng R 2000, 28: 1–63.
DOI Google Scholar
[25]
Katti KS, Katti DR. Relatioship of swelling and swelling pressure on silica–water interactions in montmorillonite. Langmuir 2006, 22: 532–537.
DOI Google Scholar
[26]
Rezwan K, Chen QZ, Blaker JJ, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006, 27: 3413–3431.
DOI Google Scholar
[27]
Vitale-Brovarone C, Miola M, Balagna C, et al. 3D-glass-ceramic scaffolds with antibacterial properties for bone grafting. Chem Eng J 2008, 137: 129–136.
DOI Google Scholar
[28]
Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005, 26: 5474–5491.
DOI Google Scholar
[29]
Smith IO, Ren F, Baumann MJ, et al. Confocal laser scanning microscopy as a tool for imaging cancellous bone. J Biomed Mater Res B 2006, 79: 185–192.
DOI Google Scholar
[30]
Woodard JR, Hilldore AJ, Lan SK, et al. The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity. Biomaterials 2007, 28: 45–54.
DOI Google Scholar
[31]
Vitale-Brovarone C, Baino F, Verné E. High strength bioactive glass-ceramic scaffolds for bone regeneration. J Mater Sci: Mater M 2009, 20: 643–653.
DOI Google Scholar
[32]
Du R, Chang J. Preparation and characterization of bioactive sol–gel-derived Na2Ca2Si3O9. J Mater Sci: Mater M 2004, 15: 1285–1289.
DOI Google Scholar
[33]
Filho OP, LaTorre GP, Hench LL. Effect of crystallization on apatite-layer formation of bioactive glass 45S5. J Biomed Mater Res 1996, 30: 509–514.
DOI
[34]
Chen QZ, Thompson ID, Boccaccini AR. 45S5 Bioglasss®-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials 2006, 27: 2414–2425.
DOI Google Scholar
[35]
Hench LL, Polak JM. Third-generation biomedical materials. Science 2002, 295: 1014–1017.
DOI Google Scholar
[36]
Hench LL. The story of Bioglass®. J Mater Sci: Mater M 2006, 17: 967–978.
DOI Google Scholar
[37]
Hench LL Bioceramics: From concept to clinic. J Am Ceram Soc 1991, 74: 1487–1510.
DOI Google Scholar
[38]
Hench LL, Andersson Ö. Bioactive glasses. In: An Introduction to Bioceramics. Hench LL, Wilson J, Eds. Singapore: World Scientific Publishing, 1993: 41–62.
DOI
Publication history
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Publication history

Received: 27 July 2015
Revised: 15 September 2015
Accepted: 14 October 2015
Published: 07 January 2016
Issue date: June 2021

Copyright

© The author(s) 2016

Acknowledgements

The authors are thankful to Mr. Femi Igbari of the College of NanoScience and Technology, Soochow University, China, for his assistance with the EDX and XRD characterisations as well as Mr. Isa Yakubu of Ahmadu Bello University Zaria for the SEM analysis.

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