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Uniform and well dispersed nano hydroxyapatite (HA)–gelatine composites were obtained by co-precipitation of hydroxyapatite and denatured calf skin collagen. The process allowed much higher concentration of hydroxyapatite to be produced over conventional hydrothermal process to improve the productivity. The effect of gelatine on the morphology, mechanical properties, and biocompatibility of hydroxyapatite particles was investigated. Fibroblast cell tests of the consolidated hydroxyapatite–gelatine composites showed that the composites have excellent biocompatibility.


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Mechanical property and biocompatibility of co-precipitated nano hydroxyapatite–gelatine composites

Show Author's information Huirong LEa( )Kiruthika NATESANbSundaram PRANTI-HARANc
School of Marine Science and Engineering, Plymouth University, United Kingdom
Peninsular Schools of Medicine and Dentistry, Plymouth University, United Kingdom
School of Engineering, Physics and Mathematics, University of Dundee, United Kingdom

Abstract

Uniform and well dispersed nano hydroxyapatite (HA)–gelatine composites were obtained by co-precipitation of hydroxyapatite and denatured calf skin collagen. The process allowed much higher concentration of hydroxyapatite to be produced over conventional hydrothermal process to improve the productivity. The effect of gelatine on the morphology, mechanical properties, and biocompatibility of hydroxyapatite particles was investigated. Fibroblast cell tests of the consolidated hydroxyapatite–gelatine composites showed that the composites have excellent biocompatibility.

Keywords:

biomaterials, nanocomposites, hydroxyapatite (HA), gelatine, biocompatibility
Received: 01 April 2015 Revised: 20 April 2015 Accepted: 03 May 2015 Published: 07 July 2015 Issue date: September 2015
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Publication history
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Publication history

Received: 01 April 2015
Revised: 20 April 2015
Accepted: 03 May 2015
Published: 07 July 2015
Issue date: September 2015

Copyright

© The author(s) 2015

Acknowledgements

The authors would like to thank all the technicians in the School of Engineering, Physics and Mathematics, University of Dundee for their assistance in the manufacture of the mould and testing rig. The authors are also indebted to Dr. Kenneth Donnelly and Dr. Robert Keatch for constructive discussions and support.

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