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Journal of Advanced Ceramics 2015, 4(2): 118-122 https://doi.org/10.1007/s40145-015-0139-z
Research Article | Open Access | Issue | Published: 30 May 2015

Fabrication of carbon coated gadolinia particles for dual-mode magnetic resonance and fluorescence imaging

Show Author's Information Timur Sh. ATABAEVa( ),  Jong Ho LEEb,  Dong-Wook HANb,  Hyung-Kook KIMa( ),  Yoon-Hwae HWANGa( )
Department of Nanomaterials Engineering, Pusan National University, Miryang 627-706, Republic of Korea
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea
Keywords:
carbon, core–shell structure, gadolinia particles, fluorescence, magnetic resonance imaging (MRI) contrast agent
Cite this article:
ATABAEV TS, LEE JH, HAN D-W, et al. Fabrication of carbon coated gadolinia particles for dual-mode magnetic resonance and fluorescence imaging. Journal of Advanced Ceramics, 2015, 4(2): 118-122. https://doi.org/10.1007/s40145-015-0139-z
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Abstract Full text About this article

In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core–shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.


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About this article

Fabrication of carbon coated gadolinia particles for dual-mode magnetic resonance and fluorescence imaging

Show Author's information Timur Sh. ATABAEVa( ), Jong Ho LEEb, Dong-Wook HANb, Hyung-Kook KIMa( ), Yoon-Hwae HWANGa( )
Department of Nanomaterials Engineering, Pusan National University, Miryang 627-706, Republic of Korea
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea

Abstract

In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core–shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.

Keywords: carbon, core–shell structure, gadolinia particles, fluorescence, magnetic resonance imaging (MRI) contrast agent

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Publication history
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Publication history

Received: 16 October 2014
Revised: 08 January 2015
Accepted: 12 January 2015
Published: 30 May 2015
Issue date: June 2015

Copyright

© The author(s) 2015

Acknowledgements

This study was financially supported by the 2014 Post-Doc, Development Program of Pusan National University. This work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2014R1A2A1A11051146).

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Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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