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In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core–shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.


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Fabrication of carbon coated gadolinia particles for dual-mode magnetic resonance and fluorescence imaging

Show Author's information Timur Sh. ATABAEVa( )Jong Ho LEEbDong-Wook HANbHyung-Kook KIMa( )Yoon-Hwae HWANGa( )
Department of Nanomaterials Engineering, Pusan National University, Miryang 627-706, Republic of Korea
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea

Abstract

In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core–shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.

Keywords:

carbon, core–shell structure, gadolinia particles, fluorescence, magnetic resonance imaging (MRI) contrast agent
Received: 16 October 2014 Revised: 08 January 2015 Accepted: 12 January 2015 Published: 30 May 2015 Issue date: June 2015
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Publication history
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Publication history

Received: 16 October 2014
Revised: 08 January 2015
Accepted: 12 January 2015
Published: 30 May 2015
Issue date: June 2015

Copyright

© The author(s) 2015

Acknowledgements

This study was financially supported by the 2014 Post-Doc, Development Program of Pusan National University. This work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2014R1A2A1A11051146).

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