AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
PDF (2.4 MB)
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Effect of different sol–gel synthesis processes on microstructural and morphological characteristics of hydroxyapatite-bioactive glass composite nanopowders

Mohamadhassan TAHERIANa,b( )Ramin ROJAEEb,cMohammadhossein FATHIb,cMorteza TAMIZIFARa
Department of Materials and Metallurgical Engineering, Iran University of Science and Technology (IUST), Tehran 16866-13114, Iran
Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran
Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Show Author Information

Abstract

The aim of this work was to study the influence of the different synthesis processes on microstructural and morphological characteristics and distribution of hydroxyapatite-bioactive glass (HAp-BG) composite nanopowders obtained by sol–gel method. HAp-BG composite nanopowders with 20 wt% bioactive glass were prepared using a sol–gel method via four routes: (I) mixing the prepared HAp solution with BG solution before aging time; (II) mixing the prepared BG solution with the prepared HAp gel after gelation; (III) mixing the calcined BG nanopowders with the prepared HAp solution; and (IV) mixing the two prepared calcined nanopowders by mechanochemical activation. The prepared nanopowders were evaluated and studied by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS), Fourier transform infrared (FTIR), transmission electron diffraction (TEM) and Brunauer–Emmet–Teller (BET) method to investigate the phase structure, microstructure and morphology, functional groups, and the size and distribution of nanopowders. Results indicated that morphology, crystallinity, crystallite size and specific surface area (SSA) of the powders are highly correspondent to the process and type of synthesis method. These findings suggest that the modified sol–gel derived HAp-BG composite nanopowders are expected to efficiently provide a possibility to produce a good candidate to use for fabrication of a bulk nanostructured HAp-BG composite for bone tissue engineering.

References

[1]
Matsunaga K, Murata H, Mizoguchi T, et al. Mechanism of incorporation of zinc into hydroxyapatite. Acta Biomater 2010, 6:2289-2293.
[2]
Iskandar ME, Aslani A, Liu H. The effects of nanostructured hydroxyapatite coating on the biodegradation and cytocompatibility of magnesium implants. J Biomed Mater Res A 2013 101A:2340-2354.
[3]
Webster TJ, Ergun C, Doremus RH, et al. Enhanced osteoclast-like cell functions on nanophase ceramics. Biomaterials 2001, 22:1327-1333.
[4]
Catledge SA, Fries MD, Vohra YK, et al. Nanostructured ceramics for biomedical implants. J Nanosci Nanotechno 2002, 2:293-312.
[5]
Kharaziha M, Fathi MH, Edris H. Development of novel aligned nanofibrous composite membranes for guided bone regeneration. J Mech Behav Biomed Mater 2013, 24:9-20.
[6]
Hong Z, Mello A, Yoshida T, et al. Osteoblast proliferation on hydroxyapatite coated substrates prepared by right angle magnetron sputtering. J Biomed Mater Res A 2010, 93:878-885.
[7]
Xu JL, Khor KA. Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method. J Inorg Biochem 2007, 101:187-195.
[8]
Xiao XF, Liu RF. Effect of suspension stability on electrophoretic deposition of hydroxyapatite coatings. Mater Lett 2006, 60:2627-2632.
[9]
Sebdani MM, Fathi MH. Preparation and characterization of hydroxyapatite–forsterite– bioactive glass nanocomposite coatings for biomedical applications. Ceram Int 2012, 38:1325-1330.
[10]
Balamurugan A, Balossier G, Michel J, et al. Sol gel derived SiO2–CaO–MgO–P2O5 bioglass system— Preparation and in vitro characterization. J Biomed Mater Res B: Appl Biomater 2007, 5: 546-553.
[11]
Sepulveda P, Jones JR, Hench LL. Bioactive sol–gel foams for tissue repair. J Biomed Mater Res A 2002, 59:340-348.
[12]
Zhai W, Lu H, Chen L, et al. Silicate bioceramics induce angiogenesis during bone regeneration. Acta Biomater 2012, 8:341-349.
[13]
Wang F, Li M, Lu Y, et al. A simple sol–gel technique for preparing hydroxyapatite nanopowders. Mater Lett 2005, 59:916-919.
[14]
Boonstra AH, Bernards TNM. The dependence of the gelation time on the hydrolysis time in a two-step SiO2 sol–gel process. J Non-Cryst Solids 1988, 105:207-213.
[15]
Rojaee R, Fathi M, Raeissi K. Controlling the degradation rate of AZ91 magnesium alloy via sol–gel derived nanostructured hydroxyapatite coating. Mat Sci Eng C 2013, 33:3817-3825.
[16]
Rojaee R, Fathi M, Raeissi K. Electrophoretic deposition of nanostructured hydroxyapatite coating on AZ91 magnesium alloy implants with different surface treatments. Appl Surf Sci 2013, 285:664-673.
[17]
Rojaee R, Fathi M, Raeissi K, et al. Electrophoretic deposition of bioactive glass nanopowders on magnesium based alloy for biomedical applications. Ceram Int 2014, 40:7879-7888.
[18]
Landi E, Tampieri A, Celotti G, et al. Densification behaviour and mechanisms of synthetic hydroxyapatites. J Eur Ceram Soc 2000, 20:2377-2387.
[19]
Fathi MH, Hanifi A, Mortazavi V. Preparation and bioactivity evaluation of bone-like hydroxyapatite nanopowder. J Mater Process Tech 2008, 202:536-542.
[20]
Hidouri M, Bouzouita K, Kooli F, et al. Thermal behaviour of magnesium-containing fluorapatite. Mater Chem Phys 2003, 80:496-505.
[21]
Andersson J, Areva S, Spliethoff B, et al. Sol–gel synthesis of a multifunctional, hierarchically porous silica/apatite composite. Biomaterials 2005, 26:6827-6835.
[22]
Kim H-W, Kim H-E, Salih V, et al. Hydroxyapatite and titania sol–gel composite coatings on titanium for hard tissue implants; Mechanical and in vitro biological performance. J Biomed Mater Res B: Appl Biomater 2005, 72B: 1-8.
[23]
Latifi SM, Fathi MH, Golozar MA. Preparation and characterisation of bioactive hydroxyapatite–silica composite nanopowders via sol–gel method for medical applications. Adv Appl Ceram 2011, 110:8-14.
[24]
Wang J, Chao Y, Wan Q, et al. Fluoridated hydroxyapatite coatings on titanium obtained by electrochemical deposition. Acta Biomater 2009, 5:1798-1807.
[25]
Fathi MH, Zahrani ME. Mechanical alloying synthesis and bioactivity evaluation of nanocrystalline fluoridated hydroxyapatite. J Cryst Growth 2009, 311:1392-1403.
[26]
Peon E, Fuentes G, Delgado JA, et al. Preparation and characterization of porous blocks of synthetic hydroxyapatite. Latin Am Appl Res 2004, 34:225-228.
[27]
Bianco A, Cacciotti I, Lombardi M. Si-substituted hydroxyapatite nanopowders: Synthesis, thermal stability and sinterability. Mater Res Bull 2009, 44:345-354.
[28]
Moghimian P, Najafi A, Afshar S, et al. Effect of low temperature on formation mechanism of calcium phosphate nano powder via precipitation method. Adv Powder Technol 2012, 23:744-751.
[29]
Rojaee R, Fathi MH, Raeissi K. Nanostructured hydroxyapatite coating for biodegradability improvement of magnesium-based alloy implant. In Advances in Bio-Mechanical Systems and Materials-Advanced Structured Materials. Ochsner A, Altenbach H, Eds. Springer International Publishing, 2013: 25-40.
[30]
Ye H, Liu XY, Hong HP. Cladding of titanium/fluorapatite composites onto Ti6Al4V substrate and the in vitro behaviour in the simulated body fluid. Appl Surf Sci 2009, 255:8126-8134.
[31]
Mostafa NY, Hassan HM, Mohamed FH. Sintering behavior and thermal stability of Na+, SiO44− and CO32− co-substituted hydroxyapatites. J Alloys Compd 2009, 479:692-698.
[32]
Mayr H, Ordung M, Zieglerc G. EPD of a nanoscale HA powder for biomedical applications. 2nd International Conference on Electrophoretic Deposition: Fundamentals and Applications, 2005.
[33]
Fathi MH, Zahrani EM. Fabrication and characterization of fluoridated hydroxyapatite nanopowders via mechanical alloying. J Alloys Compd 2009, 475:408-414.
[34]
Nasiri-Tabrizi B, Fahami A, Ebrahimi-Kahrizsangi R, et al. A study on mechanochemical behavior of CaO–P2O5–CaF2–ZrO2 system to produce fluorapatite–zirconia composite nanopowders. Powder Technol 2013, 243:59-70.
[35]
Esnaashary M, Fathi M, Ahmadian M. The effect of the two-step sintering process on consolidation of fluoridated hydroxyapatite and its mechanical properties and bioactivity. Int J Appl Ceram Tec 2014, 11:47-56.
[36]
Nathanael AJ, Lee JH, Mangalaraj D, et al. Multifunctional properties of hydroxyapatite/titania bio-nano-composites: Bioactivity and antimicrobial studies. Powder Technol 2012, 228:410-415.
[37]
Zhai W, Lu H, Wu C, et al. Stimulatory effects of the ionic products from Ca–Mg–Si bioceramics on both osteogenesis and angiogenesis in vitro. Acta Biomater 2013, 9:8004-8014.
[38]
Gupta G, El-Ghannam A, Kirakodu S, et al. Enhancement of osteoblast gene expression by mechanically compatible porous Si-rich nanocomposite. J Biomed Mater Res B: Appl Biomater 2007, 81: 387-396.
[39]
López-Noriega A, Arcos D, Izquierdo-Barba I, et al. Ordered mesoporous bioactive glasses for bone tissue regeneration. Chem Mater 2006, 18:3137-3144.
[40]
Ghomi H, Fathi MH, Edris H. Fabrication and characterization of bioactive glass/hydroxyapatite nanocomposite foam by gelcasting method. Ceram Int 2011, 37:1819-1824.
Journal of Advanced Ceramics
Pages 207-214
Cite this article:
TAHERIAN M, ROJAEE R, FATHI M, et al. Effect of different sol–gel synthesis processes on microstructural and morphological characteristics of hydroxyapatite-bioactive glass composite nanopowders. Journal of Advanced Ceramics, 2014, 3(3): 207-214. https://doi.org/10.1007/s40145-014-0111-3

1008

Views

21

Downloads

23

Crossref

N/A

Web of Science

24

Scopus

0

CSCD

Altmetrics

Received: 15 March 2014
Revised: 31 May 2014
Accepted: 06 June 2014
Published: 02 September 2014
© The author(s) 2014

Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

Return