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Regular | Open Access

All Optic-Fiber Waveguide-Coupled SPR Sensor for CRP Sensing Based on Dielectric Layer and Poly-Dopamine

Jinying MA1,2,3( ), Shixin LI1, Xiangdong HUANG2, Junfeng JIANG3,4, Tianhua XU3,4,5, Tiegen LIU3,4
School of Electronic Engineering, Tianjin University of Technology and Education, Tianjin 300222, China
School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China
Institute of Optical Fiber Sensing, Tianjin University, Tianjin 300072, China
Key Laboratory of Opto-Electronics Information Technology, Ministry of Education, Tianjin 300072, China
School of Engineering, University of Warwick, Coventry CV4 7AL, UK
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Abstract

We developed an all optic-fiber waveguide-coupled surface plasmon resonance (SPR) sensor using zirconium disulfide (ZrS2) and poly-dopamine (PDA) as the dielectric layer and biological cross-linker, respectively. This sensor can be employed to monitor the entire process of the C-reactive protein (CRP) sensing, including antibody modification and antigen detection. The design and the optimization of the optical fiber waveguide-coupled SPR sensor were realized, based on the transfer matrix method and first-principles calculations. The sensor was fabricated and characterized according to the optimized parameters. The experimental setup was implemented to measure the entire process of antibody modification and antigen detection for CRP with the detection limit of 3.21 pmol·mL−1, and the specificity tests were also carried out.

Keywords

Surface plasmon resonance (SPR)dielectric layerpoly-dopamine (PDA)C-reactive protein (CRP)

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Photonic Sensors
Volume 15 Issue 2,
June 2025
Article number: 250224
DOI: 10.1007/s13320-024-0734-0

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Cite this article:
MA J, LI S, HUANG X, et al. All Optic-Fiber Waveguide-Coupled SPR Sensor for CRP Sensing Based on Dielectric Layer and Poly-Dopamine. Photonic Sensors, 2025, 15(2): 250224. https://doi.org/10.1007/s13320-024-0734-0

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Received: 09 October 2023
Revised: 16 February 2024
Published: 01 June 2025
© The Author(s) 2024.

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.