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Regular | Open Access

Highly-Sensitive Polymer Optical Fiber SPR Sensor for Fast Immunoassay

Ying WANG1,2, Xing RAO1,2, Xun WU1,2, George Y. CHEN1,2( ), Changrui LIAO1,2, Mateusz Jakub SMIETANA3, Yiping WANG1,2 ( )
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, Shenzhen University, Shenzhen 518060, China
Division of Microsystem & Electronic Materials Technology, Institute of Microelectronics & Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland
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Abstract

A new type of human immunoglobulin G (IgG) sensors based on the surface plasmon resonance (SPR) in the low refractive index (RI) plastic optical fiber (POF) and an antibody immobilization method is presented. A 50-nm-thick gold film was formed on the polished D-shaped fiber surface by magnetron sputtering. The RI response of the POF sensor is 30049.61 nm/RIU, which is 26.5 times higher than that of single mode fiber (SMF) SPR sensors. The proposed SPR biosensor can be developed by simple and rapid modification of the gold film with 11-mercapto undecanoic acid (MUA). Upon immobilization of the goat anti-human IgG antibody, the resonance wavelength shifts by 11.2 nm. The sensor can be used to specifically detect and quantify the human IgG at concentrations down to 245.4 ng/mL with the sensitivity of 1.3277 nm per µg/mL, which offers an enhancement of 12.5-fold compared to that of the conventional SMF based SPR sensors. The proposed device may find the potential applications in the case of use at the point of care.

Keywords

Optical fiber biosensorsurface plasmon resonanceantibody immobilizationside-polished fiberplastic optical fiber

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Photonic Sensors
Volume 14 Issue 4,
December 2024
Article number: 240413
DOI: 10.1007/s13320-024-0729-x

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Cite this article:
WANG Y, RAO X, WU X, et al. Highly-Sensitive Polymer Optical Fiber SPR Sensor for Fast Immunoassay. Photonic Sensors, 2024, 14(4): 240413. https://doi.org/10.1007/s13320-024-0729-x
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Highlight Papers on Advanced Optical Sensors for Biochemical Applications

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Received: 09 November 2023
Revised: 31 January 2024
Published: 25 December 2024
© The Author(s) 2024.

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.