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Research Article | Online first | Published: 15 March 2024

Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers

Show Author's Information Fangjun Cao1,  Hui Feng1,  Jiaxin Yao2,3,  Xiang Hou1,  Tiezhi Jin1,  Junfeng Hui2,3( )
Shaanxi Key Laboratory of Qinling Ecological Security, Shaanxi Institute of Zoology, Xi’an 710072, China
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China
Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R & D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China
Keywords:
antioxidant, anti-inflammatory, oxygen-defected, molybdenum-based, nanoenzymes, diabetes ulcer wounds
Topics:
Biomaterials
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Cao F, Feng H, Yao J, et al. Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers. Nano Research, 2024, https://doi.org/10.1007/s12274-024-6601-x
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Abstract Full text Electronic supplementary material About this article

The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species, which cause a vicious circle of long-term inflammation. In the therapeutic research of metal nanoenzymes for healing diabetic ulcers, it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic efficiency. Herein, ultrasmall oxygen-deficient MoO3−X quantum dots were fabricated and employed as nanoenzymes for healing fiabetic ulcers. After PEGylation, PEGylated MoO3−X quantum dots (MoO3−X/PEG) with oxygen vacancies exhibits excellent photothermal, peroxidase/catalase-like activities. In addition, these MoO3−X/PEG showed superior properties in scavenging H2O2 and effectively inhibiting the scavenging of reactive oxygen species. More importantly, such an oxygen-defected MoO3−X/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers, inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds, which shows great application potential for promoting wound healing. This work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidase-like and catalase-like activities show great application potential for healing diabetes wound.


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Electronic supplementary material
About this article

Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers

Show Author's information Fangjun Cao1, Hui Feng1, Jiaxin Yao2,3, Xiang Hou1, Tiezhi Jin1, Junfeng Hui2,3( )
Shaanxi Key Laboratory of Qinling Ecological Security, Shaanxi Institute of Zoology, Xi’an 710072, China
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China
Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R & D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China

Abstract

The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species, which cause a vicious circle of long-term inflammation. In the therapeutic research of metal nanoenzymes for healing diabetic ulcers, it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic efficiency. Herein, ultrasmall oxygen-deficient MoO3−X quantum dots were fabricated and employed as nanoenzymes for healing fiabetic ulcers. After PEGylation, PEGylated MoO3−X quantum dots (MoO3−X/PEG) with oxygen vacancies exhibits excellent photothermal, peroxidase/catalase-like activities. In addition, these MoO3−X/PEG showed superior properties in scavenging H2O2 and effectively inhibiting the scavenging of reactive oxygen species. More importantly, such an oxygen-defected MoO3−X/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers, inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds, which shows great application potential for promoting wound healing. This work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidase-like and catalase-like activities show great application potential for healing diabetes wound.

Keywords: antioxidant, anti-inflammatory, oxygen-defected, molybdenum-based, nanoenzymes, diabetes ulcer wounds

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Publication history
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Acknowledgements

Publication history

Received: 05 February 2024
Revised: 28 February 2024
Accepted: 28 February 2024
Published: 15 March 2024

Copyright

© Tsinghua University Press 2024

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 32172436 and 32000353), Key R&D Plan of Shaanxi Province (No. 2020ZDLNY02-02), and the Science and Technology Research Project of Shaanxi Province Academy of Sciences (No. 2021k-38).

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