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Research Article | Online first | Published: 22 March 2024

Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

Show Author's Information Xinyang Li1,2,  Binbin Ding1( ),  Jing Li1,2,  Di Han1,2,  Hao Chen1,2,  Jia Tan1,2,  Qi Meng1,2,  Pan Zheng1,  Ping’an Ma1,2( ),  Jun Lin1,2( )
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Keywords:
tumor therapy, chemodynamic therapy, ferroptosis, CuPd nanoparticle, valance tailoring
Topics:
Platinum alloysTheranosticsTumors
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Li X, Ding B, Li J, et al. Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion. Nano Research, 2024, https://doi.org/10.1007/s12274-024-6552-2
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Abstract Full text Electronic supplementary material About this article

Chemodynamic therapy (CDT), an inventive approach to cancer treatment, exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species (ROS). While offering advantages over conventional treatments, the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione (GSH). In this study, we aim to address this dual challenge by delving into the role of copper valence states in CDT. Leveraging the unique attributes of copper-based nanoparticles, especially zero-valent copper nanoparticles (CuPd NPs), we aim to enhance the therapeutic potential of CDT. Our experiments reveal that zero-valent CuPd NPs outperform divalent copper nanoparticles (Ox-CuPd NPs) by displaying superior catalytic performance and sustaining ROS generation through a dual approach integrating peroxidase-like (POD-like) activity and Cu+ release. Notably, zero-valent NPs exhibit enhanced GSH depletion compared to their divalent counterparts, thereby intensifying CDT and inducing ferroptosis, ultimately resulting in high-efficiency tumor growth inhibition. These findings reveal the impact of valences on CDT, providing novel insights for the optimization and design of CDT agents.


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Electronic supplementary material
About this article

Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

Show Author's information Xinyang Li1,2, Binbin Ding1( ), Jing Li1,2, Di Han1,2, Hao Chen1,2, Jia Tan1,2, Qi Meng1,2, Pan Zheng1, Ping’an Ma1,2( ), Jun Lin1,2( )
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China

Abstract

Chemodynamic therapy (CDT), an inventive approach to cancer treatment, exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species (ROS). While offering advantages over conventional treatments, the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione (GSH). In this study, we aim to address this dual challenge by delving into the role of copper valence states in CDT. Leveraging the unique attributes of copper-based nanoparticles, especially zero-valent copper nanoparticles (CuPd NPs), we aim to enhance the therapeutic potential of CDT. Our experiments reveal that zero-valent CuPd NPs outperform divalent copper nanoparticles (Ox-CuPd NPs) by displaying superior catalytic performance and sustaining ROS generation through a dual approach integrating peroxidase-like (POD-like) activity and Cu+ release. Notably, zero-valent NPs exhibit enhanced GSH depletion compared to their divalent counterparts, thereby intensifying CDT and inducing ferroptosis, ultimately resulting in high-efficiency tumor growth inhibition. These findings reveal the impact of valences on CDT, providing novel insights for the optimization and design of CDT agents.

Keywords: tumor therapy, chemodynamic therapy, ferroptosis, CuPd nanoparticle, valance tailoring

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Publication history
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Acknowledgements

Publication history

Received: 21 November 2023
Revised: 28 January 2024
Accepted: 06 February 2024
Published: 22 March 2024

Copyright

© Tsinghua University Press 2024

Acknowledgements

Acknowledgements

This work is financially supported by the National Key Research and Development Program of China (No. 2022YFB3804500), the National Natural Science Foundation of China (Nos. 52102354, 52102180, 52202353, and 52372273), and the Science and Technology Development Planning Project of Jilin Province (Nos. 20220101070JC, 20220508089RC, and 20210402046GH). All animals in this study were handled according to a protocol approved by the Institutional Animal Care and Use Committee of Jilin University.

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