Hydrogen bond-bridged phosphorene flexible film for photodynamic inhibiting <i>Staphylococcus aureus</i>

Ziyu Wei; Wenting Li; Zhifang Liu; Yongfa Zhu; Huaqiang Cao

doi:10.1007/s12274-024-6487-7

Nano Research 2024, 17(6): 5461-5468 https://doi.org/10.1007/s12274-024-6487-7

Research Article | Issue | Published: 29 February 2024

Hydrogen bond-bridged phosphorene flexible film for photodynamic inhibiting Staphylococcus aureus

Show Author's Information Hide Author's Information Ziyu Wei^{^,^§}, Wenting Li^{^,^§}, Zhifang Liu, Yongfa Zhu(

), Huaqiang Cao(

)

Department of Chemistry, Engineering Research Center of Advanced Rare Earth Materials, Tsinghua University, Beijing 100084, China

^§ Ziyu Wei and Wenting Li contributed equally to this work.

Keywords:

Staphylococcus aureus, phosphorene, hydrogen bond-bridged, flexible film, photodynamic

Topics:

Biotechnology

Cite this article:

Wei Z, Li W, Liu Z, et al. Hydrogen bond-bridged phosphorene flexible film for photodynamic inhibiting Staphylococcus aureus. Nano Research, 2024, 17(6): 5461-5468. https://doi.org/10.1007/s12274-024-6487-7

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Abstract

Antibiotics are a widely used and effective treatment for bacterial infections. However, bacteria can gradually evolve during infection, leading to developing resistance to antibiotics, which renders previously effective treatments ineffective. Finding a useful and convenient manner to treat bacterial infections is a great challenge. Here, we report a flexible hydrogen-bond-bridged phosphorene film with photodynamic antibacterial properties and excellent mechanical properties, fabricated from electrochemical exfoliation of black phosphorus (BP). When illuminated under 700 nm light, the hydrogen bond-bridged phosphorene flexible film is capable of converting ground-state triplet oxygen (O₂) into excited-state singlet oxygen (¹O₂), destroying the structure of the membrane of Staphylococcus aureus, and eventually leading to bacterial death, via breaking the C=C of unsaturated fatty acids within the bacterial cell membrane after the reaction between ¹O₂ and unsaturated fatty acids, thus realizing a highly efficient antibacterial approach, which is supported by gas chromatography-mass spectrometry (GC-MS) technique. This work establishes an effective phototherapy platform for treating bacterial traumatic infections.

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About this article

Hydrogen bond-bridged phosphorene flexible film for photodynamic inhibiting Staphylococcus aureus

Show Author's information Hide Author's Information Ziyu Wei^{^,^§}, Wenting Li^{^,^§}, Zhifang Liu, Yongfa Zhu(

), Huaqiang Cao(

)

Department of Chemistry, Engineering Research Center of Advanced Rare Earth Materials, Tsinghua University, Beijing 100084, China

^§ Ziyu Wei and Wenting Li contributed equally to this work.

Abstract

Keywords: Staphylococcus aureus, phosphorene, hydrogen bond-bridged, flexible film, photodynamic

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Publication history

Received: 18 November 2023

Revised: 05 January 2024

Accepted: 14 January 2024

Published: 29 February 2024

Issue date: June 2024

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Acknowledgements

This work is financially supported by the National Natural Science Foundation of China (Nos. 22171158 and 22136002) and the Tribology Science Fund of the State Key Laboratory of Tribology (No. SKL TKF20B18). The authors gratefully thank Prof. Yu Yi (National Center for Nanoscience and Technology (NCNST), Chinese Academy of Sciences) for helpful discussions. The authors also appreciate Prof. Jingren Zhang (Tsinghua university) and Yijia Huang (Tsinghua university) for providing different varieties of Staphylococcus aureus.