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Nano Research 2024, 17(3): 1818-1826 https://doi.org/10.1007/s12274-023-6366-7
Research Article | Issue | Published: 25 January 2024

Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

Show Author's Information Kun Chen1,2,3( ),  Shengqiu Liu1,  Yujun Wei1
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou 510641, China
Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology, Guangzhou 510641, China
Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510641, China
Keywords:
obesity, polyoxovanadates, glucose homeostasis, inflammatory disease, lipid modification, peroxisome proliferator-activated receptor γ (PPARγ)
Topics:
Bioactivity InsulinMetabolism
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Chen K, Liu S, Wei Y. Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice. Nano Research, 2024, 17(3): 1818-1826. https://doi.org/10.1007/s12274-023-6366-7
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Abstract Full text Electronic supplementary material About this article

Obesity is closely related with insulin resistance and chronic inflammation. Here, we report that unsaturated lipid-modified polyoxovanadates (ULPOVs) can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated inflammation. Oral administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat diet. ULPOV treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) and reduces intestinal caloric intake, which may be the main reason for blood sugar and body weight control. In addition to insulin-sensitizing, PPARγ activation induced by ULPOV treatment in obese mice with atopic dermatitis (AD) promotes the type 2 T helper (TH2) cell selective responses and therapeutic effects on immune dysregulation caused by obesity. These data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.


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Electronic supplementary material
About this article

Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

Show Author's information Kun Chen1,2,3( ), Shengqiu Liu1, Yujun Wei1
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou 510641, China
Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology, Guangzhou 510641, China
Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou 510641, China

Abstract

Obesity is closely related with insulin resistance and chronic inflammation. Here, we report that unsaturated lipid-modified polyoxovanadates (ULPOVs) can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated inflammation. Oral administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat diet. ULPOV treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) and reduces intestinal caloric intake, which may be the main reason for blood sugar and body weight control. In addition to insulin-sensitizing, PPARγ activation induced by ULPOV treatment in obese mice with atopic dermatitis (AD) promotes the type 2 T helper (TH2) cell selective responses and therapeutic effects on immune dysregulation caused by obesity. These data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

Keywords: obesity, polyoxovanadates, glucose homeostasis, inflammatory disease, lipid modification, peroxisome proliferator-activated receptor γ (PPARγ)

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Publication history
Copyright
Acknowledgements

Publication history

Received: 23 October 2023
Revised: 21 November 2023
Accepted: 23 November 2023
Published: 25 January 2024
Issue date: March 2024

Copyright

© Tsinghua University Press 2024

Acknowledgements

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 22101086), the Natural Science Foundation of Guangdong Province (No. 2021A1515010271), and the Guangzhou Basic and Applied Basic Research Project (No. 202201010052).

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