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Nano Research 2024, 17(5): 4338-4349 https://doi.org/10.1007/s12274-023-6336-0
Research Article | Issue | Published: 28 December 2023

Bioinspired mineral-in-shell nanoarchitectonics: Functional empowerment of mineral precursors for guiding intradentinal mineralization

Show Author's Information Xiaoran Zheng1,§,  Yang Liu1,§,  Mingjing Li1,  Yuyan Li2,  Wanshan Gao2,  Rongmin Qiu2,  Jiaqi Xing1,  Jiaojiao Yang3,  Yantao Chen4,  Xinyuan Xu1,  Mingming Ding1,  Jun Luo1( ),  Jianshu Li1,3,5( )
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
College of Stomatology, Hospital of Stomatology Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Nanning 530021, China
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Shenzhen Key Laboratory of Environmental Chemistry and Ecological Remediation, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
Med-X Center for Material, Sichuan University, Chengdu 610041, China

§ Xiaoran Zheng and Yang Liu contributed equally to this work.

Keywords:
self-assembly, nanohybrids, biomineralization, mineral-in-shell, dentinal tubule occlusion, dental hypersensitivity
Topics:
Biomaterials
Cite this article:
Zheng X, Liu Y, Li M, et al. Bioinspired mineral-in-shell nanoarchitectonics: Functional empowerment of mineral precursors for guiding intradentinal mineralization. Nano Research, 2024, 17(5): 4338-4349. https://doi.org/10.1007/s12274-023-6336-0
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Abstract Full text Electronic supplementary material About this article

Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization processes. In this regard, we propose “mineral-in-shell nanoarchitectonics”, inspired by the nanostructure of matrix vesicles, which can influence multiple mineralization pathways. Our nanostructural design empowers mineral precursors with tailorable properties through encapsulating amorphous calcium phosphate within a multifunctional tannic acid (TA) and silk fibroin (SF) nanoshell. The bioinspired nanosystem facilitates efficient recruitment of mineral precursors throughout the dentin structures, followed by large-scale intradentinal mineralization both in vitro and in vivo, which provides persistent protection against external stimuli. Theoretical simulations combined with experimental studies attribute the success of intradentinal mineralization to the TA-SF nanoshell, which exhibits a strong affinity for the dentin structure, stabilizing amorphous precursors and thereby facilitating concomitant mineral formation. Overall, this bioinspired mineral-in-shell nanoarchitectonics shows a promising prospect for hard tissue repair and serves as a blueprint for next-generation biomineralization-associated materials.


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Abstract
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Electronic supplementary material
About this article

Bioinspired mineral-in-shell nanoarchitectonics: Functional empowerment of mineral precursors for guiding intradentinal mineralization

Show Author's information Xiaoran Zheng1,§, Yang Liu1,§, Mingjing Li1, Yuyan Li2, Wanshan Gao2, Rongmin Qiu2, Jiaqi Xing1, Jiaojiao Yang3, Yantao Chen4, Xinyuan Xu1, Mingming Ding1, Jun Luo1( ), Jianshu Li1,3,5( )
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
College of Stomatology, Hospital of Stomatology Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Nanning 530021, China
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Shenzhen Key Laboratory of Environmental Chemistry and Ecological Remediation, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
Med-X Center for Material, Sichuan University, Chengdu 610041, China

§ Xiaoran Zheng and Yang Liu contributed equally to this work.

Abstract

Effective mineralization of biological structures poses a significant challenge in hard tissue engineering as it necessitates overcoming geometric complexities and multistep biomineralization processes. In this regard, we propose “mineral-in-shell nanoarchitectonics”, inspired by the nanostructure of matrix vesicles, which can influence multiple mineralization pathways. Our nanostructural design empowers mineral precursors with tailorable properties through encapsulating amorphous calcium phosphate within a multifunctional tannic acid (TA) and silk fibroin (SF) nanoshell. The bioinspired nanosystem facilitates efficient recruitment of mineral precursors throughout the dentin structures, followed by large-scale intradentinal mineralization both in vitro and in vivo, which provides persistent protection against external stimuli. Theoretical simulations combined with experimental studies attribute the success of intradentinal mineralization to the TA-SF nanoshell, which exhibits a strong affinity for the dentin structure, stabilizing amorphous precursors and thereby facilitating concomitant mineral formation. Overall, this bioinspired mineral-in-shell nanoarchitectonics shows a promising prospect for hard tissue repair and serves as a blueprint for next-generation biomineralization-associated materials.

Keywords: self-assembly, nanohybrids, biomineralization, mineral-in-shell, dentinal tubule occlusion, dental hypersensitivity

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Publication history
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Acknowledgements

Publication history

Received: 07 August 2023
Revised: 15 November 2023
Accepted: 17 November 2023
Published: 28 December 2023
Issue date: May 2024

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

We are grateful for the financial support provided by the National Natural Science Foundation of China (Nos. 52273135, 51925304, and 52203180). We thank L. Z. Sun, L. Zhen, and S. Y. Tao for the technical assistance and valuable discussions.

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