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Nano Research 2024, 17(5): 4314-4328 https://doi.org/10.1007/s12274-023-6296-4
Research Article | Issue | Published: 02 December 2023

Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy

Show Author's Information Hongmei Liu1,  Jiming Xu1,  Mengjie Ye1,  Hengbo Zhang1,  Linlin Han1,  Jingting Wang1,  Peng Xue1,3,  Yuejun Kang1,3,  Zhigang Xu1,2,3( )
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Materials and Energy & Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China
Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
Yibin Academy of Southwest University, Yibin 644000, China
Keywords:
self-shrinkage, dynamic supramolecular nanoparticles, tumor energy metabolism, NIR-II mild photothermal therapy, mitochondrial oxidative stress
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Nano biology
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Liu H, Xu J, Ye M, et al. Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy. Nano Research, 2024, 17(5): 4314-4328. https://doi.org/10.1007/s12274-023-6296-4
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Abstract Full text Electronic supplementary material About this article

Photothermal therapy (PTT) may lead to healthy tissue damage, tumor metastasis, and recurrence, which makes mild photothermal therapy (mild PTT) stand out. However, overcoming heat resistance, insufficient therapeutic effect, and poor photothermal conversion efficiency has become new challenge. Herein, we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan (denoted as SDA), the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine (LND) and NIR-II photothermal agent of IR-1061, producing SDLI with a tighter inner hole, smaller and uniform particle size and excellent stability due to multiple pulling forces. Moreover, the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity, and the photothermal conversion efficiency (PCE) can reach 48.9%. At the acidic tumor microenvironment of pH 6.5, the controlled release of LND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild PTT. Meanwhile, SDLI also shows a reasonable tumor inhibition rate, so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress, continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment.


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Electronic supplementary material
About this article

Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy

Show Author's information Hongmei Liu1, Jiming Xu1, Mengjie Ye1, Hengbo Zhang1, Linlin Han1, Jingting Wang1, Peng Xue1,3, Yuejun Kang1,3, Zhigang Xu1,2,3( )
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Materials and Energy & Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China
Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
Yibin Academy of Southwest University, Yibin 644000, China

Abstract

Photothermal therapy (PTT) may lead to healthy tissue damage, tumor metastasis, and recurrence, which makes mild photothermal therapy (mild PTT) stand out. However, overcoming heat resistance, insufficient therapeutic effect, and poor photothermal conversion efficiency has become new challenge. Herein, we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan (denoted as SDA), the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine (LND) and NIR-II photothermal agent of IR-1061, producing SDLI with a tighter inner hole, smaller and uniform particle size and excellent stability due to multiple pulling forces. Moreover, the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity, and the photothermal conversion efficiency (PCE) can reach 48.9%. At the acidic tumor microenvironment of pH 6.5, the controlled release of LND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild PTT. Meanwhile, SDLI also shows a reasonable tumor inhibition rate, so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress, continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment.

Keywords: self-shrinkage, dynamic supramolecular nanoparticles, tumor energy metabolism, NIR-II mild photothermal therapy, mitochondrial oxidative stress

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Publication history
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Acknowledgements

Publication history

Received: 29 August 2023
Revised: 24 October 2023
Accepted: 30 October 2023
Published: 02 December 2023
Issue date: May 2024

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 22375168), Chongqing Talents of Exceptional Young Talents Project, China (Nos. CQYC202005029 and cstc2021ycjh-bgzxm0061), Shuangcheng cooperative agreement research grant of Yibin, China (No. XNDX2022020013) and the Innovation Platform for Academicians of Hainan Province.

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