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Review Article

Advances of nanoparticles in transmucosal drug delivery

Li Zhang1,7,§, Changwei Yang2,§, Yingxiang Song1,7,§, Tao Sheng2, Junyan Li2,3, Jicheng Yu2,3,4,5,6( ), Xiaohong Wu1,7( ), Xiao Ye1,7 ( )
Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou 310014, China
Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Jinhua Institute of Zhejiang University, Jinhua 321299, China
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China
Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province, Hangzhou 310014, China

§ Li Zhang, Changwei Yang, and Yingxiang Song contributed equally to this work.

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Abstract

Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site. However, many challenges still remain in its clinical application, including low drug availability and limited retention time in the mucosa. The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations, leveraging their distinct advantages of high drug-loading capacity and strong permeability. In this review, the latest developments of nanoparticles (NPs) in transmucosal drug delivery as well as their clinical applications are discussed.

Graphical Abstract

This work elucidated the successful synthesis of a self-supported electrode for hydrogen evolution reaction (HER) in water electrolysis. The WS2/N-rGO/CC (nitrogen-doped reduced graphene oxide (N-rGO) nanoflakes and WS2 hierarchical nanoflower grown directly on carbon cloth (CC) substrate) electrode achieved excellent stability and durability at a high current density, meanwhile exhibiting lower overpotential and Tafel slope compared to Pt-based catalysts, making it a promising alternative for practical applications in energy-saving hydrogen production.

Keywords

nanoparticles (NPs)transmucosal drug deliverymucosal barriersbiomaterials

References

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Nano Research
Volume 17 Issue 4,
April 2024
Pages 2874-2885
DOI: 10.1007/s12274-023-6188-7

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Cite this article:
Zhang L, Yang C, Song Y, et al. Advances of nanoparticles in transmucosal drug delivery. Nano Research, 2024, 17(4): 2874-2885. https://doi.org/10.1007/s12274-023-6188-7
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Received: 29 July 2023
Revised: 09 September 2023
Accepted: 11 September 2023
Published: 21 November 2023
© Tsinghua University Press 2023