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Nano Research 2023, 16(11): 12453-12470 https://doi.org/10.1007/s12274-023-6158-0
Review Article | Issue | Published: 10 October 2023

Iron oxide nanoparticles: A promising approach for diagnosis and treatment of cardiovascular diseases

Show Author's Information Xue Bao1,§,  Yu Mao1,2,§,  Guangxiang Si2,  Lina Kang1,  Biao Xu1( ),  Ning Gu1,2( )
Cardiovascular Disease Research Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China

§ Xue Bao and Yu Mao contributed equally to this work.

Keywords:
treatment, diagnosis, atherosclerosis, cardiovascular disease, iron oxide nanoparticles, theranostic
Topics:
CardiologyCardiovascular system Medical applications
Cite this article:
Bao X, Mao Y, Si G, et al. Iron oxide nanoparticles: A promising approach for diagnosis and treatment of cardiovascular diseases. Nano Research, 2023, 16(11): 12453-12470. https://doi.org/10.1007/s12274-023-6158-0
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Abstract Full text About this article

Despite advances in diagnostic and therapeutic technologies for cardiovascular diseases (CVDs), it remains a leading cause of mortality and morbidity worldwide. This underscores the urgency for innovative approaches aiming at early and precise detection and treatment of CVDs to reduce the disease burden. Iron oxide nanoparticles (IONPs), with their unique magnetism and bioproperties, have shown great potential in this regard. In this review, we will begin with a brief overview of the synthesis and properties of IONPs. We will then focus on the latest applications of IONPs in CVDs, including diagnosis and treatment. The use of IONPs in the integration of diagnosis and treatment for CVDs is a promising field, and will be addressed in a separate section. The translational potential and challenges of IONPs will also be discussed. In conclusion, ongoing research and development of IONP-based strategies are highly likely to address current challenges effectively, and offer more personalized and efficient options for the diagnosis and treatment of CVDs.


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About this article

Iron oxide nanoparticles: A promising approach for diagnosis and treatment of cardiovascular diseases

Show Author's information Xue Bao1,§, Yu Mao1,2,§, Guangxiang Si2, Lina Kang1, Biao Xu1( ), Ning Gu1,2( )
Cardiovascular Disease Research Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China

§ Xue Bao and Yu Mao contributed equally to this work.

Abstract

Despite advances in diagnostic and therapeutic technologies for cardiovascular diseases (CVDs), it remains a leading cause of mortality and morbidity worldwide. This underscores the urgency for innovative approaches aiming at early and precise detection and treatment of CVDs to reduce the disease burden. Iron oxide nanoparticles (IONPs), with their unique magnetism and bioproperties, have shown great potential in this regard. In this review, we will begin with a brief overview of the synthesis and properties of IONPs. We will then focus on the latest applications of IONPs in CVDs, including diagnosis and treatment. The use of IONPs in the integration of diagnosis and treatment for CVDs is a promising field, and will be addressed in a separate section. The translational potential and challenges of IONPs will also be discussed. In conclusion, ongoing research and development of IONP-based strategies are highly likely to address current challenges effectively, and offer more personalized and efficient options for the diagnosis and treatment of CVDs.

Keywords: treatment, diagnosis, atherosclerosis, cardiovascular disease, iron oxide nanoparticles, theranostic

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Publication history
Copyright
Acknowledgements

Publication history

Received: 30 June 2023
Revised: 03 September 2023
Accepted: 04 September 2023
Published: 10 October 2023
Issue date: November 2023

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

This work was financially supported by the National Key R&D Program of Ministry of Science and Technology (No. 2022YFA1205904), the National Natural Science Innovative Research Group Project (No. 61821002), the Key Project of the National Natural Science Foundation of China (No. 51832001), the Frontier Fundamental Research Program of Jiangsu Province for Leading Technology (No. BK20222002), the Jiangsu Planned Projects for Postdoctoral Research Funds (No. 2021K287B), the National Natural Science Foundation of China (Nos. 82100478, and 52302349) and the open research fund of Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University (No. 202201). The authors also would like to acknowledge Freepik.com for providing assets to create the graphs.

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