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Review Article

Iron oxide nanoparticles: A promising approach for diagnosis and treatment of cardiovascular diseases

Xue Bao1,§, Yu Mao1,2,§, Guangxiang Si2, Lina Kang1, Biao Xu1( ), Ning Gu1,2 ( )
Cardiovascular Disease Research Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China

§ Xue Bao and Yu Mao contributed equally to this work.

Show Author Information

In the realm of academic pursuits, we often find ourselves indebted to the trailblazers who have propelled our understanding and paved the way for further advancements. Professor Xie Sishen is such a true pioneer in the field of nanotechnology and its applications. His immense contributions and unwavering dedication have left an indelible mark on our discipline. As we remember and honor his great accomplishments, may we be motivated by his fervor and commitment, ensuring that his everlasting influence continues to direct and inspire upcoming generations.

Abstract

Despite advances in diagnostic and therapeutic technologies for cardiovascular diseases (CVDs), it remains a leading cause of mortality and morbidity worldwide. This underscores the urgency for innovative approaches aiming at early and precise detection and treatment of CVDs to reduce the disease burden. Iron oxide nanoparticles (IONPs), with their unique magnetism and bioproperties, have shown great potential in this regard. In this review, we will begin with a brief overview of the synthesis and properties of IONPs. We will then focus on the latest applications of IONPs in CVDs, including diagnosis and treatment. The use of IONPs in the integration of diagnosis and treatment for CVDs is a promising field, and will be addressed in a separate section. The translational potential and challenges of IONPs will also be discussed. In conclusion, ongoing research and development of IONP-based strategies are highly likely to address current challenges effectively, and offer more personalized and efficient options for the diagnosis and treatment of CVDs.

Graphical Abstract

In this review, we summarized the latest applications of iron oxide nanoparticles in the diagnosis and treatment of cardiovascular diseases, with a particular interest in their translational potential and associated challenges. This graphic was made with assets from Freepik.com (www.freepik.com).

Keywords

atherosclerosiscardiovascular diseasediagnosisiron oxide nanoparticlestheranostictreatment

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Nano Research
Volume 16 Issue 11,
November 2023
Pages 12453-12470
DOI: 10.1007/s12274-023-6158-0

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Cite this article:
Bao X, Mao Y, Si G, et al. Iron oxide nanoparticles: A promising approach for diagnosis and treatment of cardiovascular diseases. Nano Research, 2023, 16(11): 12453-12470. https://doi.org/10.1007/s12274-023-6158-0
Topics:
CardiologyCardiovascular system Medical applications

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Received: 30 June 2023
Revised: 03 September 2023
Accepted: 04 September 2023
Published: 10 October 2023
© Tsinghua University Press 2023