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Nano Research 2024, 17(2): 602-617 https://doi.org/10.1007/s12274-023-6108-x
Review Article | Issue | Published: 08 September 2023

Superwettable interface towards biodetection in confined space

Show Author's Information Zexu Pang,  Zhikang Cao,  Wanlu Li,  Wenxia Xu,  Yingying Zhang,  Qitao Zhou,  Jing Pan( ),  Fan Xia
State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
Keywords:
interface, confined space, superwettability, biodetection
Topics:
Diagnosis
Cite this article:
Pang Z, Cao Z, Li W, et al. Superwettable interface towards biodetection in confined space. Nano Research, 2024, 17(2): 602-617. https://doi.org/10.1007/s12274-023-6108-x
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Abstract Full text About this article

The detection of biomarkers with both high sensitivity and specificity is crucial for the diagnosis and treatment of related diseases. However, many current detections employ ex-situ detection method and non-confined condition, thus have many problems, which may eventually lead to inaccurate detection results. Compared to detection in non-confined space, detection in confined space can better reflect the real in-vivo situation. Therefore, the construction of detection for target molecules in confined space has great significance for both theoretical research and practical application. To realize the detection of target molecules in confined space, the probes should accurately enter the confined space where the target molecules reside and interact with the interface. Thus, how to explore and utilize the properties of the interface (for example, bioinspired superwettability) has always been a hot and difficult topic in this field. Herein, the recent advances and our efforts in recent 10 years on detection of bio-target molecules in confined space with superwettable interface have been introduced from the perspective of the detection methods. The suitable and most widely employed detection methods for target molecules in confined spaces are introduced firstly. Then, recent progresses for related detections based on visual, optical, and electrochemical detection methods are presented successively. Finally, the perspective for detection in confined space is discussed for the future development of biochemical detection.


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About this article

Superwettable interface towards biodetection in confined space

Show Author's information Zexu Pang, Zhikang Cao, Wanlu Li, Wenxia Xu, Yingying Zhang, Qitao Zhou, Jing Pan( ), Fan Xia
State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China

Abstract

The detection of biomarkers with both high sensitivity and specificity is crucial for the diagnosis and treatment of related diseases. However, many current detections employ ex-situ detection method and non-confined condition, thus have many problems, which may eventually lead to inaccurate detection results. Compared to detection in non-confined space, detection in confined space can better reflect the real in-vivo situation. Therefore, the construction of detection for target molecules in confined space has great significance for both theoretical research and practical application. To realize the detection of target molecules in confined space, the probes should accurately enter the confined space where the target molecules reside and interact with the interface. Thus, how to explore and utilize the properties of the interface (for example, bioinspired superwettability) has always been a hot and difficult topic in this field. Herein, the recent advances and our efforts in recent 10 years on detection of bio-target molecules in confined space with superwettable interface have been introduced from the perspective of the detection methods. The suitable and most widely employed detection methods for target molecules in confined spaces are introduced firstly. Then, recent progresses for related detections based on visual, optical, and electrochemical detection methods are presented successively. Finally, the perspective for detection in confined space is discussed for the future development of biochemical detection.

Keywords: interface, confined space, superwettability, biodetection

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Publication history
Copyright
Acknowledgements

Publication history

Received: 30 June 2023
Revised: 14 August 2023
Accepted: 17 August 2023
Published: 08 September 2023
Issue date: February 2024

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 22204150), GuangDong Basic and Applied Basic Research Foundation (No. 2021A1515110036), the National Key R&D Program of China (Nos. 2021YFA1200403 and 2018YFE0206900), the Joint NSFC-ISF Research Grant Program (No. 22161142020).

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