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Nano Research 2023, 16(12): 13113-13133 https://doi.org/10.1007/s12274-023-6051-x
Review Article | Issue | Published: 13 October 2023

PFAS in PMs might be the escalating hazard to the lung health

Show Author's Information Yue Pan1,2,§,  Jie Mei2,3,§,  Jipeng Jiang4,§,  Ke Xu2,3,  Xinglong Gao2,3,  Shasha Jiang4,  Ying Liu2( )
Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450052, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
University of Chinese Academy of Sciences, Beijing 100049, China
Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

§ Yue Pan, Jie Mei, and Jipeng Jiang contributed equally to this work.

Keywords:
PM2.5, lung, pulmonary homeostasis, environment pollution, per- and polyfluorinated alkyl substances (PFASs)
Topics:
Health risks
Cite this article:
Pan Y, Mei J, Jiang J, et al. PFAS in PMs might be the escalating hazard to the lung health. Nano Research, 2023, 16(12): 13113-13133. https://doi.org/10.1007/s12274-023-6051-x
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Abstract Full text About this article

Atmospheric particulate matter (PM) is a dominant source of air pollution, in particular, molecules less than 2.5 μm in diameter, endangering human health. An estimated 2.1 million deaths from exposure to PM2.5 and 700,000 cases of respiratory disease caused by atmospheric pollution were reported on an annual basis. The main components of PM2.5 include heavy metal elements, water-soluble ions, carbon aerosols, ozone, and organic compounds. Per- and polyfluoroalkyl substances (PFASs) are a large group of representative pollutants among the organic compounds absorbed in PM2.5. PFASs are widely used in industrial production and hardly degraded in the environment, resulting in their accumulation in water, food, and air, and abosorbed by humans via ingestion and inhalation. On the other hand, accumulation of PFAS in the human body is proving to be associated with some unfavorable health outcomes, whereas the mechanisms underlying the effects of PFAS exposure on human lung diseases remain unclear at present. The toxicological effects of organic components are a significant focus of research. This review will fix our attention on the changes in the distribution, composition, and content of PFAS in PM2.5 by location and year, and provide an overview on the influence of PM2.5 and PFAS on lung health, with indications of possible synergistic adverse effects of PM2.5 and PFAS on pulmonary homeostasis.


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About this article

PFAS in PMs might be the escalating hazard to the lung health

Show Author's information Yue Pan1,2,§, Jie Mei2,3,§, Jipeng Jiang4,§, Ke Xu2,3, Xinglong Gao2,3, Shasha Jiang4, Ying Liu2( )
Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450052, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
University of Chinese Academy of Sciences, Beijing 100049, China
Department of Thoracic Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

§ Yue Pan, Jie Mei, and Jipeng Jiang contributed equally to this work.

Abstract

Atmospheric particulate matter (PM) is a dominant source of air pollution, in particular, molecules less than 2.5 μm in diameter, endangering human health. An estimated 2.1 million deaths from exposure to PM2.5 and 700,000 cases of respiratory disease caused by atmospheric pollution were reported on an annual basis. The main components of PM2.5 include heavy metal elements, water-soluble ions, carbon aerosols, ozone, and organic compounds. Per- and polyfluoroalkyl substances (PFASs) are a large group of representative pollutants among the organic compounds absorbed in PM2.5. PFASs are widely used in industrial production and hardly degraded in the environment, resulting in their accumulation in water, food, and air, and abosorbed by humans via ingestion and inhalation. On the other hand, accumulation of PFAS in the human body is proving to be associated with some unfavorable health outcomes, whereas the mechanisms underlying the effects of PFAS exposure on human lung diseases remain unclear at present. The toxicological effects of organic components are a significant focus of research. This review will fix our attention on the changes in the distribution, composition, and content of PFAS in PM2.5 by location and year, and provide an overview on the influence of PM2.5 and PFAS on lung health, with indications of possible synergistic adverse effects of PM2.5 and PFAS on pulmonary homeostasis.

Keywords: PM2.5, lung, pulmonary homeostasis, environment pollution, per- and polyfluorinated alkyl substances (PFASs)

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Publication history
Copyright
Acknowledgements

Publication history

Received: 28 April 2023
Revised: 27 July 2023
Accepted: 28 July 2023
Published: 13 October 2023
Issue date: December 2023

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

This work was supported by the Major Research Plan-Integrated Program of National Natural Science Foundation of China (No. 92143301), the National Natural Science Foundation of China (No. 31971318), and Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (No. CIFMS 2019-I2M-5-018).

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