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Research Article

Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform

Junhui Sui1,2,§, Mingda Zhao1,§, Zhihao Guo5,§, Jiafeng Li4, Jie Chen2, Hongli Chen3, Jie Liang1, Yong Sun1( ), Xingdong Zhang1, Yujiang Fan1( )
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
Beijing Tide Pharmaceutical Co., Ltd., Beijing 100176, China
The Key Laboratory of Biomedical Material, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China
Coal Mining Branch, China Coal Research Institute, Beijing 100028, China
School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China

§ Junhui Sui, Mingda Zhao, and Zhihao Guo contributed equally to this work.

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Graphical Abstract

Herein, an all-in-one functional absorbable sponges (HCNPs) with hemostatic effect was constructed by integrating PP-Dox/Lap (doxorubicin (Dox) and lapatinib (Lap) synergistic delivery nanoparticles) into thiolated hyaluronic acid (HA-SH) and collagen I cross-linked hydrogel for effective preventing post-resection recurrence as well as distant metastasis. The functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer.

Abstract

Locoregional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’ survival. To address the clinical challenge, functional absorbable sponges (HA-SH/PP-Dox/Lap/COL I (HCNPs)) were constructed by biomimetic extracellular matrix of collagen I / hyaluronic acid complex conjugated with doxorubicin/lapatinib (Dox/Lap)-loaded nanoparticles. The HCNPs sponge exhibited excellent clotting ability and blood absorption rate. Worthily, Dox/Lap-loaded nanoparticles were synchronously endowed with a large number of oligo hyaluronic acid segments after degradation, which thus enhanced the ability of targeting into CD44-overexpressed tumor cells. The implantable HCNPs sponge in resected cavity of postoperative 4T1 models inhibited the spread of scattered tumor cells by absorbing the inevitable bleeding. More importantly, CD44 targeted nanoparticle with suitable Dox/Lap proportion continuously released from sponge to kill tumor cells of surrounding HCNPs and those remaining at surgical margin, thus prevented local recurrence as well as distant metastasis. Therefore, the functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer.

Keywords

therapeutic spongescattered tumor cellsrecurrence and metastasisCD44-targeted nanoparticlesbreast cancer

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Nano Research
Volume 17 Issue 3,
March 2024
Pages 1792-1803
DOI: 10.1007/s12274-023-6017-z
Cite this article:
Sui J, Zhao M, Guo Z, et al. Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform. Nano Research, 2024, 17(3): 1792-1803. https://doi.org/10.1007/s12274-023-6017-z
Topics:
Controlled drug deliveryTumors

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Received: 22 May 2023
Revised: 16 July 2023
Accepted: 18 July 2023
Published: 05 August 2023
© Tsinghua University Press 2023
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