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Nano Research 2024, 17(2): 771-777 https://doi.org/10.1007/s12274-023-5886-5
Research Article | Issue | Published: 01 July 2023

Biomimetic chitin hydrogel via chemical transformation

Show Author's Information Rui-Rui Liu1,  Qian-Qian Shi2,3,  Yu-Feng Meng1,  Yong Zhou2,3( ),  Li-Bo Mao1( ),  Shu-Hong Yu1( )
Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, University of Science and Technology of China, Hefei 230026, China
College & Hospital of Stomatology, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei 230032, China
Department of Dental Implantology, College & Hospital of Stomatology, Anhui Medical University, Hefei 230032, China
Keywords:
chemical stability, mechanical strength, biomimetic structure, antifouling, chitin hydrogel
Topics:
Fabrication
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Liu R-R, Shi Q-Q, Meng Y-F, et al. Biomimetic chitin hydrogel via chemical transformation. Nano Research, 2024, 17(2): 771-777. https://doi.org/10.1007/s12274-023-5886-5
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Abstract Full text Electronic supplementary material About this article

Chitin hydrogel has been recognized as a promising material for various biomedical applications because of its biocompatibility and biodegradability. However, the fabrication of strong chitin hydrogel remains a big challenge because of the insolubility of chitin in many solvents and the reduced chain length of chitin regenerated from solutions. We herein introduce the fabrication of chitin hydrogel with biomimetic structure through the chemical transformation of chitosan, which is a water-soluble deacetylated derivative of chitin. The reacetylation of the amino group in chitosan endows the obtained chitin hydrogel with outstanding resistance to swelling, degradation, extreme temperature and pH conditions, and organic solvents. The chitin hydrogel has excellent mechanical properties while retaining a high water content (more than 95 wt.%). It also shows excellent antifouling performance that it resists the adhesion of proteins, bacteria, blood, and cells. Moreover, as the initial chitosan solution can be feasibly frozen and templated by ice crystals, the chitin hydrogel structure can be either nacre-like or wood-like depending on the freezing method of the precursory chitosan solution. Owing to these anisotropic structures, such chitin hydrogel can exhibit anisotropic mechanics and mass transfer capabilities. The current work provides a rational strategy to fabricate chitin hydrogels and paves the way for its practical applications as a superior biomedical material.


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Electronic supplementary material
About this article

Biomimetic chitin hydrogel via chemical transformation

Show Author's information Rui-Rui Liu1, Qian-Qian Shi2,3, Yu-Feng Meng1, Yong Zhou2,3( ), Li-Bo Mao1( ), Shu-Hong Yu1( )
Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, University of Science and Technology of China, Hefei 230026, China
College & Hospital of Stomatology, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei 230032, China
Department of Dental Implantology, College & Hospital of Stomatology, Anhui Medical University, Hefei 230032, China

Abstract

Chitin hydrogel has been recognized as a promising material for various biomedical applications because of its biocompatibility and biodegradability. However, the fabrication of strong chitin hydrogel remains a big challenge because of the insolubility of chitin in many solvents and the reduced chain length of chitin regenerated from solutions. We herein introduce the fabrication of chitin hydrogel with biomimetic structure through the chemical transformation of chitosan, which is a water-soluble deacetylated derivative of chitin. The reacetylation of the amino group in chitosan endows the obtained chitin hydrogel with outstanding resistance to swelling, degradation, extreme temperature and pH conditions, and organic solvents. The chitin hydrogel has excellent mechanical properties while retaining a high water content (more than 95 wt.%). It also shows excellent antifouling performance that it resists the adhesion of proteins, bacteria, blood, and cells. Moreover, as the initial chitosan solution can be feasibly frozen and templated by ice crystals, the chitin hydrogel structure can be either nacre-like or wood-like depending on the freezing method of the precursory chitosan solution. Owing to these anisotropic structures, such chitin hydrogel can exhibit anisotropic mechanics and mass transfer capabilities. The current work provides a rational strategy to fabricate chitin hydrogels and paves the way for its practical applications as a superior biomedical material.

Keywords: chemical stability, mechanical strength, biomimetic structure, antifouling, chitin hydrogel

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Publication history
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Acknowledgements

Publication history

Received: 10 April 2023
Revised: 20 May 2023
Accepted: 29 May 2023
Published: 01 July 2023
Issue date: February 2024

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

This work was supported by the National Key Research and Development Program of China (Nos. 2018YFE0202201 and 2021YFA0715700), the National Natural Science Foundation of China (Nos. 21701161 and 22293044), and the Key Scientific Research Foundation of the Education Department of Anhui Province (No. 2022AH050702). This work was partially carried out at the USTC Center for Micro- and Nanoscale Research and Fabrication. The authors thank Dr. Rundong Wang and Prof. Binghong Zhan from Beijing Institute of Fashion Technology for their assistance in visualizing the scheme of this work.

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