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Research Article

A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity

Zhiyu Yang1,2,4, Xiaoya Guo1,2,4, Meng Meng1,2,4, Tong Li1,2,4, Huapan Fang3,5( ), Zhaohui Tang1,2,4, Huayu Tian1,2,3,4,5( ), Xuesi Chen1,2,4
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China
Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, China
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Abstract

As a revolutionary cancer treatment strategy, immunotherapy has attracted great attention. However, the effect of immunotherapy such as immune checkpoint blockade (ICB) is usually limited by insufficient immune response in the body. Herein, a polycation-based magnetic nanocluster platform was developed to load therapeutic nucleic acids, which could achieve gene therapy-mediated ICB and efficient magnetic hyperthermia therapy (MHT). The silencing of immune checkpoints together with MHT-induced immunogenic cell death (ICD) effectively alleviated the immune escape of cancer cells and significantly enhanced the visibility of cancer cells to the immune system. This combined treatment strategy activated a strong adaptive anti-cancer immune response in vivo, greatly inhibiting tumor growth, metastasis and recurrence.

Graphical Abstract

A magnetic nanoplatform capable of loading nucleic acids has been developed to achieve the combination of immune checkpoint silencing and magnetic hyperthermia for anti-cancer immunity.

Keywords

magnetic nanoclustersgene therapyimmune checkpoint silencingmagnetic hyperthermia therapycancer immunotherapy

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Nano Research
Volume 16 Issue 8,
August 2023
Pages 11206-11215
DOI: 10.1007/s12274-023-5839-z

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Cite this article:
Yang Z, Guo X, Meng M, et al. A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity. Nano Research, 2023, 16(8): 11206-11215. https://doi.org/10.1007/s12274-023-5839-z
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Received: 29 March 2023
Revised: 08 May 2023
Accepted: 11 May 2023
Published: 10 June 2023
© Tsinghua University Press 2023