This research was supported by the National Key R&D Program of China (Nos. 2022YFA0913200, 2021YFF0701800, 2022YFF0710000, and 2020YFA0908900), the National Natural Science Foundation of China (Nos. 22107097, 22020102003, 22277064, 82272161, and 22125701), Tsinghua University Spring Breeze Fund grant (No. 2021Z99CFZ005), and the Youth Innovation Promotion Association of CAS (No. 2021226) All animal experiments were conducted in compliance with the Animal Management Rules of the Ministry of Health of the People's Republic of China, and with the approval of the Institutional Animal Care and Use Committee of the Animal Experiment Center of Jilin University (No. PZPX20180929070).