This research was supported by the National Basic Research Program of China (973 Program, No. 2012CB933600), the National Natural Science Foundation of China (Nos. 81771964 and 82072051) and the Shanghai Municipal Natural Science Foundation (No. 15ZR1408500). This work was funded by the Special Project of Clinical Research of Health Industry of Shanghai Municipal Health Commission (No. 201940178), the Scientific Research Project of Hongkou District Health Committee of Shanghai (No. 2002-17), the Clinical Research Project of Wu Jieping Medical Foundation (No. 320.6750.2020-18-2), and the Research Project of Shanghai Fourth People’s Hospital (No. sykyqd 00701＆00702).