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Nano Research 2024, 17(2): 426-444 https://doi.org/10.1007/s12274-023-5606-1
Review Article | Issue | Published: 14 April 2023

Organic thin-film transistors and related devices in life and health monitoring

Show Author's Information Chenfang Sun( ),  Tie Wang( )
Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin 300384, China
Keywords:
biomarkers, healthcare, biosensors, organic semiconductors, organic thin-film transistors, organic bioelectronics
Topics:
Field effect transistorsHealth careNanosensors Organic field effect transistorsOrganic semiconductor materialsSemiconducting films Semiconductor devices Thin film transistors
Cite this article:
Sun C, Wang T. Organic thin-film transistors and related devices in life and health monitoring. Nano Research, 2024, 17(2): 426-444. https://doi.org/10.1007/s12274-023-5606-1
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Abstract Full text Electronic supplementary material About this article

The early determination of disease-related biomarkers can significantly improve the survival rate of patients. Thus, a series of explorations for new diagnosis technologies, such as optical and electrochemical methods, have been devoted to life and health monitoring. Organic thin-film transistor (OTFT), as a state-of-the-art nano-sensing technology, has attracted significant attention from construction to application owing to the merits of being label-free, low-cost, facial, and rapid detection with multi-parameter responses. Nevertheless, interference from non-specific adsorption is inevitable in complex biological samples such as body liquid and exhaled gas, so the reliability and accuracy of the biosensor need to be further improved while ensuring sensitivity, selectivity, and stability. Herein, we overviewed the composition, mechanism, and construction strategies of OTFTs for the practical determination of disease-related biomarkers in both body fluids and exhaled gas. The results show that the realization of bio-inspired applications will come true with the rapid development of high-effective OTFTs and related devices.


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Abstract
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Electronic supplementary material
About this article

Organic thin-film transistors and related devices in life and health monitoring

Show Author's information Chenfang Sun( ), Tie Wang( )
Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin 300384, China

Abstract

The early determination of disease-related biomarkers can significantly improve the survival rate of patients. Thus, a series of explorations for new diagnosis technologies, such as optical and electrochemical methods, have been devoted to life and health monitoring. Organic thin-film transistor (OTFT), as a state-of-the-art nano-sensing technology, has attracted significant attention from construction to application owing to the merits of being label-free, low-cost, facial, and rapid detection with multi-parameter responses. Nevertheless, interference from non-specific adsorption is inevitable in complex biological samples such as body liquid and exhaled gas, so the reliability and accuracy of the biosensor need to be further improved while ensuring sensitivity, selectivity, and stability. Herein, we overviewed the composition, mechanism, and construction strategies of OTFTs for the practical determination of disease-related biomarkers in both body fluids and exhaled gas. The results show that the realization of bio-inspired applications will come true with the rapid development of high-effective OTFTs and related devices.

Keywords: biomarkers, healthcare, biosensors, organic semiconductors, organic thin-film transistors, organic bioelectronics

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Publication history
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Acknowledgements

Publication history

Received: 26 December 2022
Revised: 21 February 2023
Accepted: 22 February 2023
Published: 14 April 2023
Issue date: February 2024

Copyright

© Tsinghua University Press 2023

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 21925405, 22104141, 22104142, 22004122, and 201874005), the National Key Research and Development Program of China Grant (Nos. 2018YFA0208800 and 2021YFD1700300), the Chinese Academy of Sciences (Nos. XDA23030106 and YJKYYQ20180044), and the China Postdoctoral Science Foundation (Nos. 2020M680676 and 2021T140680).

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