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Nano Research 2023, 16(5): 6361-6368 https://doi.org/10.1007/s12274-023-5459-7
Research Article | Issue | Published: 22 February 2023

Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

Show Author's Information Xiaodong Ji1,  Xin Zhao2( ),  Zixin Zhang1,  Yunfa Si1,  Wei Qian2,  Huaqiang Fu1,  Zibo Chen1,  Zhe Wang3,  Huihui Jin4( ),  Zhugen Yang5,  Daping He1,2( )
State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China
Hubei Engineering Research Center of RF-Microwave Technology and Application, Wuhan University of Technology, Wuhan 430070, China
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
School of Information Engineering, Wuhan University of Technology, Wuhan 430070, China
School of Water, Energy and Environment, Cranfield University, Milton Keynes, MK43 0AL, UK
Keywords:
graphene film, ultra-high conductivity, multifunctional electrode, point-of-care diagnosis, wearable medical devices
Topics:
Graphene devices
Cite this article:
Ji X, Zhao X, Zhang Z, et al. Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose. Nano Research, 2023, 16(5): 6361-6368. https://doi.org/10.1007/s12274-023-5459-7
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Abstract Full text Electronic supplementary material About this article

Conventional glassy carbon electrodes (GCE) cannot meet the requirements of future electrodes for wider use due to low conductivity, high cost, non-portability, and lack of flexibility. Therefore, cost-effective and wearable electrode enabling rapid and versatile molecule detection is becoming important, especially with the ever-increasing demand for health monitoring and point-of-care diagnosis. Graphene is considered as an ideal electrode due to its excellent physicochemical properties. Here, we prepare graphene film with ultra-high conductivity and customize the 3-electrode system via a facile and highly controllable laser engraving approach. Benefiting from the ultra-high conductivity (5.65 × 105 S·m−1), the 3-electrode system can be used as multifunctional electrode for direct detection of dopamine (DA) and enzyme-based detection of glucose without further metal deposition. The dynamic ranges from 1–200 μM to 0.5–8.0 mM were observed for DA and glucose, respectively, with a limit of detection (LOD) of 0.6 μM and 0.41 mM. Overall, the excellent target detection capability caused by the ultra-high conductivity and ease modification of graphene films, together with their superb mechanical properties and ease of mass-produced, provides clear potential not only for replacing GCE for various electrochemical studies but also for the development of portable and high-performance electrochemical wearable medical devices.


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Abstract
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Electronic supplementary material
About this article

Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

Show Author's information Xiaodong Ji1, Xin Zhao2( ), Zixin Zhang1, Yunfa Si1, Wei Qian2, Huaqiang Fu1, Zibo Chen1, Zhe Wang3, Huihui Jin4( ), Zhugen Yang5, Daping He1,2( )
State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China
Hubei Engineering Research Center of RF-Microwave Technology and Application, Wuhan University of Technology, Wuhan 430070, China
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
School of Information Engineering, Wuhan University of Technology, Wuhan 430070, China
School of Water, Energy and Environment, Cranfield University, Milton Keynes, MK43 0AL, UK

Abstract

Conventional glassy carbon electrodes (GCE) cannot meet the requirements of future electrodes for wider use due to low conductivity, high cost, non-portability, and lack of flexibility. Therefore, cost-effective and wearable electrode enabling rapid and versatile molecule detection is becoming important, especially with the ever-increasing demand for health monitoring and point-of-care diagnosis. Graphene is considered as an ideal electrode due to its excellent physicochemical properties. Here, we prepare graphene film with ultra-high conductivity and customize the 3-electrode system via a facile and highly controllable laser engraving approach. Benefiting from the ultra-high conductivity (5.65 × 105 S·m−1), the 3-electrode system can be used as multifunctional electrode for direct detection of dopamine (DA) and enzyme-based detection of glucose without further metal deposition. The dynamic ranges from 1–200 μM to 0.5–8.0 mM were observed for DA and glucose, respectively, with a limit of detection (LOD) of 0.6 μM and 0.41 mM. Overall, the excellent target detection capability caused by the ultra-high conductivity and ease modification of graphene films, together with their superb mechanical properties and ease of mass-produced, provides clear potential not only for replacing GCE for various electrochemical studies but also for the development of portable and high-performance electrochemical wearable medical devices.

Keywords: graphene film, ultra-high conductivity, multifunctional electrode, point-of-care diagnosis, wearable medical devices

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Publication history
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Acknowledgements

Publication history

Received: 04 December 2022
Revised: 25 December 2022
Accepted: 29 December 2022
Published: 22 February 2023
Issue date: May 2023

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51672204 and 22102128), the Fundamental Research Funds for the Central Universities (WUT: 2021IVA66, WUT: 2022IVA172, and WUT: 2020IB005), and the Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City (No. 520LH054).

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