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Nano Research 2023, 16(5): 7373-7382 https://doi.org/10.1007/s12274-023-5458-8
Research Article | Issue | Published: 21 January 2023

Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

Show Author's Information Rui Gu1,  Wanlan Yang1,  Lifei Han3,  Chao Liu1,  Yatao Xu1,  Yunlong Liu2,  Weili Si1( ),  Wenjun Wang2,  Xiaochen Dong1,4( )
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China
School of Physical Science and Information Technology, Liaocheng University, Liaocheng 252059, China
Breast Disease Center. Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, China
Keywords:
carbon monoxide, gas therapy, mitochondrial, endoplasmic reticulum
Topics:
Controlled drug deliveryTheranostics
Cite this article:
Gu R, Yang W, Han L, et al. Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy. Nano Research, 2023, 16(5): 7373-7382. https://doi.org/10.1007/s12274-023-5458-8
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Abstract Full text Electronic supplementary material About this article

The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca3(PO4)2 acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO.


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Abstract
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Electronic supplementary material
About this article

Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

Show Author's information Rui Gu1, Wanlan Yang1, Lifei Han3, Chao Liu1, Yatao Xu1, Yunlong Liu2, Weili Si1( ), Wenjun Wang2, Xiaochen Dong1,4( )
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China
School of Physical Science and Information Technology, Liaocheng University, Liaocheng 252059, China
Breast Disease Center. Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, China

Abstract

The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca3(PO4)2 acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO.

Keywords: carbon monoxide, gas therapy, mitochondrial, endoplasmic reticulum

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Publication history
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Acknowledgements

Publication history

Received: 01 December 2022
Revised: 23 December 2022
Accepted: 23 December 2022
Published: 21 January 2023
Issue date: May 2023

Copyright

© Tsinghua University Press 2023

Acknowledgements

Acknowledgements

The work was supported by the National Natural Science Foundation of China (Nos. 21975121 and 22175089), Jiangsu Provincial key research and development plan (No. BE2021711), and Taishan scholars’ construction special fund of Shandong Province.

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