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Research Article

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

Xianyun Wang1,2,3,4,5,6, Shiqi Hu5,6, Dashuai Zhu5,6, Junlang Li5,6, Ke Cheng5,6( ), Gang Liu1,3,4( )
Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China
Scientific Research Data Center, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China
Hebei Key Laboratory of Cardiac Injury Repair Mechanism Study, Shijiazhuang 050000, China
Hebei International Joint Research Center for Structural Heart Disease, Shijiazhuang 050000, China
Department of Molecular Biomedical Science, North Carolina State University, Raleigh 27607, North Carolina, USA
Department of Biomedical Engineering, University of North Carolina, Chapel Hill and North Carolina State University, Raleigh 27607, North Carolina, USA
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Abstract

Extracellular vesicles (EVs) generated from mesenchymal stem cells (MSCs) play an essential role in modulating cell–cell communication and tissue regeneration. The clinical translation of EVs is constrained by the poor yield of EVs. Extrusion has recently become an effective technique for producing a large scale of nanovesicles (NVs). In this study, we systematically compared MSC NVs (from extrusion) and EVs (from natural secretion). Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs. Additionally, microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis. Lastly, intravenous delivery of MSC NVs improved heart repair and cardiac function in a mouse model of myocardial infarction.

Graphical Abstract

Systematic comparison analysis of mesenchymal stem cell (MSC) derived nanovesicles (NVs) (from extrusion) and extracellular vesicles (EVs) (from natural secretion) was performed in this study.

Keywords

nanovesicles (NVs)exosomescardiac repairmesenchymal stem cells (MSCs)extracellular vesicles (EVs)myocardial infarction (MI)

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Nano Research
Volume 16 Issue 5,
May 2023
Pages 7248-7259
DOI: 10.1007/s12274-023-5374-3

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Cite this article:
Wang X, Hu S, Zhu D, et al. Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials. Nano Research, 2023, 16(5): 7248-7259. https://doi.org/10.1007/s12274-023-5374-3
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Received: 02 August 2022
Revised: 30 November 2022
Accepted: 03 December 2022
Published: 28 February 2023
© Tsinghua University Press 2023