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Nanozyme antibacterial agents with high enzyme-like catalytic activity and strong bacteria-binding ability have provided an alternative method to efficiently disinfect drug-resistance microorganism. Herein, the carbon nitride quantum dots (CNQDs) nanozymes with high nitrogen vacancies (NVs) were mass-productively prepared by a simple ultrasonic-crushing method assisted by propylene glycol. It was found that the NVs of CNQDs were stemmed from the selective breaking of surface N-(C)2 sites, accounting for 6.2%. Experiments and density functional theory (DFT) simulations have demonstrated that the presence of NVs can alter the local electron distribution and extend the π-electron delocalization to enhance the peroxidase-like activity. Biocompatible CNQDs could enter inside microorganisms by diffusion and elevate the bacteria-binding ability, which enhanced the accurate and rapid attack of ·OH to the microorganisms. The sterilization rate of CNQDs against Gram-negative bacteria (E. coli), Gram-positive bacteria (S. aureus, B. subtilis), and fungi (R. solani) reaches more than 99%. Thus, this work showed great potential for engineered nanozymes for broad-spectrum antibacterial in biomedicine and environmental protection.
This work was supported by the National Natural Science Foundation of China (Nos. 21876099, 22106088, and 22276110), Key Research & Developmental Program of Shandong Province (No. 2021CXGC011202), and Fundamental Research Funds of Shandong University (No. zy202102).