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Research Article

A hydrogel system containing molybdenum-based nanomaterials for wound healing

Yongzhou Lu1,§, Chuanlong Jia1,§, Chengchen Gong1,§, Han Wang2, Qin Xiao1, Jinxiao Guo3( ), Dalong Ni2( ), Nan Xu1( )
Department of Dermatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

§ Yongzhou Lu, Chuanlong Jia, and Chengchen Gong contributed equally to this work.

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Abstract

Wound delayed healing or non-healing has seriously affected patients’ quality of life and has been a significant economic burden for public health systems worldwide. Excess reactive oxygen species (ROS) play important roles for impeding the process of wound healing. Herein, we report a hydrogel system containing low-valence-state molybdenum nanomaterials (Mo hydrogel) for wound healing by scavenging the detrimental ROS. Both in vitro and in vivo results demonstrate that the synthesized Mo hydrogel can accelerate wound healing, promote angiogenesis, and stimulate the expression of growth factors. Since the molybdenum is an essential element for the survival of all organisms, such novel Mo-hydrogel has the great potential to be clinically translated for wound healing.

Graphical Abstract

A novel multi-antioxidant in the form of Mo hydrogel for wound healing in living animals was presented. Our findings revealed that the Mo-based nanomaterials exhibited broad antioxidative activities against multiple toxic reactive oxygen species (ROS), which were confirmed to protect cells against harmful oxidative stress.

Keywords

antioxidantswound healinghydrogelreactive oxygen speciesmolybdenum

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Nano Research
Volume 16 Issue 4,
April 2023
Pages 5368-5375
DOI: 10.1007/s12274-022-5255-9

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Cite this article:
Lu Y, Jia C, Gong C, et al. A hydrogel system containing molybdenum-based nanomaterials for wound healing. Nano Research, 2023, 16(4): 5368-5375. https://doi.org/10.1007/s12274-022-5255-9
Topics:
NanobiotechnologyTissue regeneration

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Received: 08 September 2022
Revised: 23 October 2022
Accepted: 27 October 2022
Published: 11 January 2023
© Tsinghua University Press 2022