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Research Article

A hydrogel system containing molybdenum-based nanomaterials for wound healing

Yongzhou Lu1,§, Chuanlong Jia1,§, Chengchen Gong1,§, Han Wang2, Qin Xiao1, Jinxiao Guo3( ), Dalong Ni2( ), Nan Xu1( )
Department of Dermatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

§ Yongzhou Lu, Chuanlong Jia, and Chengchen Gong contributed equally to this work.

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Graphical Abstract

A novel multi-antioxidant in the form of Mo hydrogel for wound healing in living animals was presented. Our findings revealed that the Mo-based nanomaterials exhibited broad antioxidative activities against multiple toxic reactive oxygen species (ROS), which were confirmed to protect cells against harmful oxidative stress.

Abstract

Wound delayed healing or non-healing has seriously affected patients’ quality of life and has been a significant economic burden for public health systems worldwide. Excess reactive oxygen species (ROS) play important roles for impeding the process of wound healing. Herein, we report a hydrogel system containing low-valence-state molybdenum nanomaterials (Mo hydrogel) for wound healing by scavenging the detrimental ROS. Both in vitro and in vivo results demonstrate that the synthesized Mo hydrogel can accelerate wound healing, promote angiogenesis, and stimulate the expression of growth factors. Since the molybdenum is an essential element for the survival of all organisms, such novel Mo-hydrogel has the great potential to be clinically translated for wound healing.

Keywords

antioxidantswound healinghydrogelreactive oxygen speciesmolybdenum

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References

[1]

Landén, N. X.; Li, D. Q.; Ståhle, M. Transition from inflammation to proliferation: A critical step during wound healing. Cell. Mol. Life Sci. 2016, 73, 3861–3885.
Crossref Google Scholar
[2]

Malone, M.; Radzieta, M.; Schwarzer, S.; Jensen, S. O.; Lavery, L. A. Efficacy of a topical concentrated surfactant gel on microbial communities in non-healing diabetic foot ulcers with chronic biofilm infections: A proof-of-concept study. Int. Wound J. 2021, 18, 457–466.
Crossref Google Scholar
[3]

Eming, S. A.; Martin, P.; Tomic-Canic, M. Wound repair and regeneration: Mechanisms, signaling, and translation. Sci. Transl. Med. 2014, 6, 265sr6.
Crossref Google Scholar
[4]

Sanchez, M. C.; Lancel, S.; Boulanger, E.; Neviere, R. Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: A systematic review. Antioxidants 2018, 7, 98.
Crossref Google Scholar
[5]

Dworzański, J.; Strycharz-Dudziak, M.; Kliszczewska, E.; Kiełczykowska, M.; Dworzańska, A.; Drop, B.; Polz-Dacewicz, M. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein–Barr virus. PLoS One 2020, 15, e0230374.
Crossref Google Scholar
[6]

Obrosova, I. G. Update on the pathogenesis of diabetic neuropathy. Curr. Diab. Rep. 2003, 3, 439–445.
Crossref Google Scholar
[7]

Rosenberger, D. C.; Blechschmidt, V.; Timmerman, H.; Wolff, A.; Treede, R. D. Challenges of neuropathic pain: Focus on diabetic neuropathy. J. Neural Transm. 2020, 127, 589–624.
Crossref Google Scholar
[8]

Wu, J. J. X.; Wang, X. Y.; Wang, Q.; Lou, Z. P.; Li, S. R.; Zhu, Y. Y.; Qin, L.; Wei, H. Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes (II). Chem. Soc. Rev. 2019, 48, 1004–1076.
Crossref Google Scholar
[9]

Zhang, R. F.; Fan, K. L.; Yan, X. Y. Nanozymes: Created by learning from nature. Sci. China Life Sci. 2020, 63, 1183–1200.
Crossref Google Scholar
[10]

Lin, Y. H.; Ren, J. S.; Qu, X. G. Catalytically active nanomaterials: A promising candidate for artificial enzymes. Acc. Chem. Res. 2014, 47, 1097–1105.
Crossref Google Scholar
[11]

Xu, J. G.; Cai, R.; Zhang, Y. G.; Mu, X. Y. Molybdenum disulfide-based materials with enzyme-like characteristics for biological applications. Colloids Surf. B Biointerfaces 2021, 200, 111575.
Crossref Google Scholar
[12]

Huang, X. Y.; Hu, D. W.; Zhao, F. J. Molybdenum: More than an essential element. J. Exp. Bot. 2022, 73, 1766–1774.
Crossref Google Scholar
[13]

Thulabandu, V.; Chen, D. M.; Atit, R. P. Dermal fibroblast in cutaneous development and healing. Wiley Interdiscip. Rev. Dev. Biol. 2018, 7, e307.
Crossref Google Scholar
[14]

Niu, Y. M.; Li, Q.; Ding, Y.; Dong, L.; Wang, C. M. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Adv. Drug Deliv. Rev. 2019, 146, 190–208.
Crossref Google Scholar
[15]

Chen, Q. R.; Hou, H.; Wang, S. K.; Zhao, X.; Li, B. F. Effects of early enteral nutrition supplemented with collagen peptides on post-burn inflammatory responses in a mouse model. Food Funct. 2017, 8, 1933–1941.
Crossref Google Scholar
[16]

Begum, F.; Keni, R.; Ahuja, T. N.; Beegum, F.; Nandakumar, K.; Shenoy, R. R. Notch signaling: A possible therapeutic target and its role in diabetic foot ulcers. Diabetes Metab. Syndr. Clin. Res. Rev. 2022, 16, 102542.
Crossref Google Scholar
[17]

Kimball, A. S.; Joshi, A. D.; Boniakowski, A. E.; Schaller, M.; Chung, J.; Allen, R.; Bermick, J.; Carson, W. F. I.; Henke, P. K.; Maillard, I. et al. Notch regulates macrophage-mediated inflammation in diabetic wound healing. Front. Immunol. 2017, 8, 635.
Crossref Google Scholar
[18]

Jia, C. L.; Lu, Y. Z.; Bi, B.; Chen, L.; Yang, Q. J.; Yang, P.; Guo, Y.; Zhu, J. J.; Zhu, N. W.; Liu, T. Y. Platelet-rich plasma ameliorates senescence-like phenotypes in a cellular photoaging model. RSC Adv. 2017, 7, 3152–3160.
Crossref Google Scholar
[19]

Jiang, Y. H.; Zhao, W. T.; Xu, S. S.; Wei, J. J.; Lasaosa, F. L.; He, Y. Y.; Mao, H. L.; Bailo, R. M. B.; Kong, D. L.; Gu, Z. W. Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization. Biomaterials 2022, 280, 121323.
Crossref Google Scholar
[20]

Ma, T. F.; Zhai, X. Y.; Huang, Y. K.; Zhang, M. Z.; Zhao, X. L.; Du, Y. P.; Yan, C. H. A smart nanoplatform with photothermal antibacterial capability and antioxidant activity for chronic wound healing. Adv. Healthc. Mater. 2021, 10, 2100033.
Crossref Google Scholar
[21]

Lin, Y.; Liu, X. Y.; Liu, Z. X.; Xu, Y. H. Visible-light-driven photocatalysis-enhanced nanozyme of TiO2 nanotubes@MoS2 nanoflowers for efficient wound healing infected with multidrug-resistant bacteria. Small 2022, 17, 2201184.
Crossref Google Scholar
[22]

Huang, H. Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: Recent advances. Sensors 2018, 18, 3249.
Crossref Google Scholar
[23]

Da Rocha-Azevedo, B.; Ho, C. H.; Grinnell, F. PDGF stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2. Mol. Biol. Cell 2015, 26, 1098–1105.
Crossref Google Scholar
[24]

Raziyeva, K.; Kim, Y.; Zharkinbekov, Z.; Kassymbek, K.; Jimi, S.; Saparov, A. Immunology of acute and chronic wound healing. Biomolecules 2021, 11, 700.
Crossref Google Scholar
[25]

Borena, B. M.; Martens, A.; Broeckx, S. Y.; Meyer, E.; Chiers, K.; Duchateau, L.; Spaas, J. H. Regenerative skin wound healing in mammals: State-of-the-art on growth factor and stem cell based treatments. Cell. Physiol. Biochem. 2015, 36, 1–23.
Crossref Google Scholar
[26]

Komi, D. E. A.; Khomtchouk, K.; Santa Maria, P. L. A review of the contribution of mast cells in wound healing: Involved molecular and cellular mechanisms. Clin. Rev. Allergy Immunol. 2020, 58, 298–312.
Crossref Google Scholar
[27]

Fukushima, T.; Uchiyama, S.; Tanaka, H.; Kataoka, H. Hepatocyte growth factor activator: A proteinase linking tissue injury with repair. Int. J. Mol. Sci. 2018, 19, 3435.
Crossref Google Scholar
[28]

Miyagi, H.; Thomasy, S. M.; Russell, P.; Murphy, C. J. The role of hepatocyte growth factor in corneal wound healing. Exp. Eye Res. 2018, 166, 49–55.
Crossref Google Scholar
[29]

Wang, X. J.; Banda, J.; Qi, H.; Chang, A. K.; Bwalya, C.; Chao, L.; Li, X. K. Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2. Cytokine Growth Factor Rev. 2022, 66, 26–37.
Crossref Google Scholar
[30]

He, M.; Han, T.; Wang, Y.; Wu, Y. H.; Qin, W. S.; Du, L. Z.; Zhao, C. Q. Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation-induced corneal neovascularization. Int. J. Mol. Med. 2019, 43, 1888–1899.
Crossref Google Scholar
Nano Research
Volume 16 Issue 4,
April 2023
Pages 5368-5375
DOI: 10.1007/s12274-022-5255-9
Cite this article:
Lu Y, Jia C, Gong C, et al. A hydrogel system containing molybdenum-based nanomaterials for wound healing. Nano Research, 2023, 16(4): 5368-5375. https://doi.org/10.1007/s12274-022-5255-9
Topics:
NanobiotechnologyTissue regeneration

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Received: 08 September 2022
Revised: 23 October 2022
Accepted: 27 October 2022
Published: 11 January 2023
© Tsinghua University Press 2022
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