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Nano Research 2023, 16(4): 5368-5375 https://doi.org/10.1007/s12274-022-5255-9
Research Article | Issue | Published: 11 January 2023

A hydrogel system containing molybdenum-based nanomaterials for wound healing

Show Author's Information Yongzhou Lu1,§,  Chuanlong Jia1,§,  Chengchen Gong1,§,  Han Wang2,  Qin Xiao1,  Jinxiao Guo3( ),  Dalong Ni2( ),  Nan Xu1( )
Department of Dermatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

§ Yongzhou Lu, Chuanlong Jia, and Chengchen Gong contributed equally to this work.

Keywords:
hydrogel, wound healing, reactive oxygen species, antioxidants, molybdenum
Topics:
NanobiotechnologyTissue regeneration
Cite this article:
Lu Y, Jia C, Gong C, et al. A hydrogel system containing molybdenum-based nanomaterials for wound healing. Nano Research, 2023, 16(4): 5368-5375. https://doi.org/10.1007/s12274-022-5255-9
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Abstract Full text Electronic supplementary material About this article

Wound delayed healing or non-healing has seriously affected patients’ quality of life and has been a significant economic burden for public health systems worldwide. Excess reactive oxygen species (ROS) play important roles for impeding the process of wound healing. Herein, we report a hydrogel system containing low-valence-state molybdenum nanomaterials (Mo hydrogel) for wound healing by scavenging the detrimental ROS. Both in vitro and in vivo results demonstrate that the synthesized Mo hydrogel can accelerate wound healing, promote angiogenesis, and stimulate the expression of growth factors. Since the molybdenum is an essential element for the survival of all organisms, such novel Mo-hydrogel has the great potential to be clinically translated for wound healing.


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Electronic supplementary material
About this article

A hydrogel system containing molybdenum-based nanomaterials for wound healing

Show Author's information Yongzhou Lu1,§, Chuanlong Jia1,§, Chengchen Gong1,§, Han Wang2, Qin Xiao1, Jinxiao Guo3( ), Dalong Ni2( ), Nan Xu1( )
Department of Dermatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

§ Yongzhou Lu, Chuanlong Jia, and Chengchen Gong contributed equally to this work.

Abstract

Wound delayed healing or non-healing has seriously affected patients’ quality of life and has been a significant economic burden for public health systems worldwide. Excess reactive oxygen species (ROS) play important roles for impeding the process of wound healing. Herein, we report a hydrogel system containing low-valence-state molybdenum nanomaterials (Mo hydrogel) for wound healing by scavenging the detrimental ROS. Both in vitro and in vivo results demonstrate that the synthesized Mo hydrogel can accelerate wound healing, promote angiogenesis, and stimulate the expression of growth factors. Since the molybdenum is an essential element for the survival of all organisms, such novel Mo-hydrogel has the great potential to be clinically translated for wound healing.

Keywords: hydrogel, wound healing, reactive oxygen species, antioxidants, molybdenum

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Publication history
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Acknowledgements

Publication history

Received: 08 September 2022
Revised: 23 October 2022
Accepted: 27 October 2022
Published: 11 January 2023
Issue date: April 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

We greatly acknowledge the financial support from the National Natural Science Foundation of China (Nos. 82102190 and 81773347), Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No. 20191805), and the Foundation of National Facility for Translational Medicine (Shanghai) (No. TMSK-2021-122).

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