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Nano Research 2023, 16(4): 5279-5291 https://doi.org/10.1007/s12274-022-5199-0
Research Article | Issue | Published: 19 January 2023

De novo engineering of nanoformulation from traditional Chinese medicine mixtures for psoriasis

Show Author's Information Yang Li1,§,  Dan Zhang2,§,  Tianzi Shi1,  Yulin Yu1,  Yinmei Tian1,  Qi Xie1,  Jingyu Shi3,  Li Kong1,  Conglian Yang1( ),  Zhiping Zhang1,4( )
Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China
Department of Pharmacy, Wuhan No.1 Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430022, China
Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430077, China
Hubei Engineering Research Centre for Novel Drug Delivery System, Wuhan 430030, China

§ Yang Li and Dan Zhang contributed equally to this work.

Keywords:
traditional Chinese medicine, nanostructures, nanotechnology, psoriasis, glycyrrhiza protein
Topics:
Drug deliveryDrug therapy
Cite this article:
Li Y, Zhang D, Shi T, et al. De novo engineering of nanoformulation from traditional Chinese medicine mixtures for psoriasis. Nano Research, 2023, 16(4): 5279-5291. https://doi.org/10.1007/s12274-022-5199-0
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Abstract Full text Electronic supplementary material About this article

Nanotechnology has been widely applied in the development of traditional Chinese medicine (TCM). Interestingly, we found that nanostructures intrinsically existed in 12 clinically applied TCM mixtures (TCMMs). However, the role of these nanostructures in TCMMs and their potential value in improving the development of TCMMs remain unknown. Taking Qingxuechushi mixture as an example, we demonstrated that nanoparticles could be the most efficient part through the pharmacodynamics study on psoriasis model. By imitating the physical properties and chemical composition of isolated nanoparticles in Qingxuechushi mixture, a novel nanoformulation with definite components and good therapeutic effect was developed, which not only mimicked the prescription composition rules in the original TCMMs but also possessed the advantage of nanotechnology. This novel nanoformulation could notably alleviate the psoriasis-like manifestations and reduce the levels of pro-inflammatory factors in serum in the psoriasis mouse model. This work organically integrates the advantages of TCMMs and nanotechnology, which may provide a new approach and inspiration for the development of TCM.


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Electronic supplementary material
About this article

De novo engineering of nanoformulation from traditional Chinese medicine mixtures for psoriasis

Show Author's information Yang Li1,§, Dan Zhang2,§, Tianzi Shi1, Yulin Yu1, Yinmei Tian1, Qi Xie1, Jingyu Shi3, Li Kong1, Conglian Yang1( ), Zhiping Zhang1,4( )
Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China
Department of Pharmacy, Wuhan No.1 Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430022, China
Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430077, China
Hubei Engineering Research Centre for Novel Drug Delivery System, Wuhan 430030, China

§ Yang Li and Dan Zhang contributed equally to this work.

Abstract

Nanotechnology has been widely applied in the development of traditional Chinese medicine (TCM). Interestingly, we found that nanostructures intrinsically existed in 12 clinically applied TCM mixtures (TCMMs). However, the role of these nanostructures in TCMMs and their potential value in improving the development of TCMMs remain unknown. Taking Qingxuechushi mixture as an example, we demonstrated that nanoparticles could be the most efficient part through the pharmacodynamics study on psoriasis model. By imitating the physical properties and chemical composition of isolated nanoparticles in Qingxuechushi mixture, a novel nanoformulation with definite components and good therapeutic effect was developed, which not only mimicked the prescription composition rules in the original TCMMs but also possessed the advantage of nanotechnology. This novel nanoformulation could notably alleviate the psoriasis-like manifestations and reduce the levels of pro-inflammatory factors in serum in the psoriasis mouse model. This work organically integrates the advantages of TCMMs and nanotechnology, which may provide a new approach and inspiration for the development of TCM.

Keywords: traditional Chinese medicine, nanostructures, nanotechnology, psoriasis, glycyrrhiza protein

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Publication history
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Acknowledgements

Publication history

Received: 03 July 2022
Revised: 12 October 2022
Accepted: 13 October 2022
Published: 19 January 2023
Issue date: April 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This research was supported by the National Natural Science Foundation of China (Nos. 82173760 and 82104098), the Program for HUST Academic Frontier Youth Team (No. 2018QYTD13), and Scientific Research Project of Wuhan Municipal Health Commission (No. WX20Q16). Thanks to the TEM provided by the Analytical and Testing Center of Huazhong University of Science and Technology.

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