Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Runkai Lv; Zhengzheng Qian; Xiaopeng Zhao; Fei Xiong; Yingjie Xu; Wenpei Fan; Xikuang Yao; Wei Huang

doi:10.1007/s12274-022-5184-7

Nano Research 2023, 16(4): 5685-5694 https://doi.org/10.1007/s12274-022-5184-7

Research Article | Issue | Published: 15 November 2022

Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Show Author's Information Hide Author's Information Runkai Lv^¹, Zhengzheng Qian^², Xiaopeng Zhao^¹, Fei Xiong^¹, Yingjie Xu^², Wenpei Fan^²(

), Xikuang Yao^¹(

), Wei Huang^{¹^,³^,⁴}(

)

1School of Flexible Electronics (Future Technologies) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China

2State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China

3Frontiers Science Center for Flexible Electronics, Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials and Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi’an 710072, China

4Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China

Keywords:

tumor therapy, drug delivery system, gold nanovesicles, polymer-induced self-assembly, biodegradable copolymers

Topics:

Nano biology Gold nanoparticles

Cite this article:

Lv R, Qian Z, Zhao X, et al. Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy. Nano Research, 2023, 16(4): 5685-5694. https://doi.org/10.1007/s12274-022-5184-7

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Abstract Full text Electronic supplementary material About this article

Abstract

Polymer-induced self-assembly of inorganic nanoparticles has emerged as a powerful strategy for fabrication of stimuli-responsive drug delivery nanosystems. Herein, we designed and synthesized a series of lipoic acid-capped polysarcosine-b-polycaprolactone (PSar-b-PCL) block copolymers. The self-assembly of gold nanoparticles drove by these block copolymers was systematically investigated, and the preparation of near-infrared (NIR) light-responsive PSar-decorated gold nanovesicle (PSGV) was optimized. DOX as anticancer drug was efficiently encapsulated within the cavity of PSGV. The PSGV greatly prevented doxorubicin (DOX) from premature leakage. While upon 808 nm laser irradiation, most of loaded DOX was rapidly released, along with the recovery of DOX fluorescence. Impressively, the DOX-loaded PSGV (DOX-PSGV) exhibited much higher cell uptake efficiency when compared to DOX-loaded polyethylene glycol (PEG)-coated gold nanovesicle (DOX-PEGV). Thanks to the synergistic photothermal/chemo therapy, the DOX-PSGV had highly superior antitumor efficacy in established 4T1 tumor model.

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About this article

Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Show Author's information Hide Author's Information Runkai Lv^¹, Zhengzheng Qian^², Xiaopeng Zhao^¹, Fei Xiong^¹, Yingjie Xu^², Wenpei Fan^²(

), Xikuang Yao^¹(

), Wei Huang^{¹^,³^,⁴}(

)

1School of Flexible Electronics (Future Technologies) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China

4Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China

Abstract

Keywords: tumor therapy, drug delivery system, gold nanovesicles, polymer-induced self-assembly, biodegradable copolymers

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Acknowledgements

Publication history

Received: 11 August 2022

Revised: 03 October 2022

Accepted: 10 October 2022

Published: 15 November 2022

Issue date: April 2023

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Acknowledgements

This work was supported by the financial support from the Natural Science Foundation of Jiangsu Province (No. BK20200709), the Natural Science Foundation of the Jiangsu Higher Education Institutes (No. 20KJB430031), and the startup fund from Nanjing Tech University.