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Nano Research 2023, 16(4): 5140-5154 https://doi.org/10.1007/s12274-022-5145-1
Review Article | Issue | Published: 05 December 2022

Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging

Show Author's Information Xiaoming Hu1,2,  Fengwei Sun1,  Caijun Zhu2,  Zhen Yang1( ),  Wei Huang1,3( )
Strait Laboratory of Flexible Electronics (SLoFE), Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University, Fuzhou 350117, China
Jiangxi Key Laboratory of Nanobiomaterials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China
Frontiers Science Center for Flexible Electronics (FSCFE), MIIT Key Laboratory of Flexible Electronics (KLoFE), Northwestern Polytechnical University, Xi’an 710072, China
Keywords:
malignant tumor, infections, organic semiconducting nanomaterials, second near-infrared (NIR-II) fluorescence imaging, organic injury
Topics:
Medical imaging
Cite this article:
Hu X, Sun F, Zhu C, et al. Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging. Nano Research, 2023, 16(4): 5140-5154. https://doi.org/10.1007/s12274-022-5145-1
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Abstract Full text About this article

Optical imaging possesses important implications for early disease diagnosis, timely disease treatment, and basic medical as well as biological research. Compared with the traditionary near-infrared (NIR-I) window (650–950 nm) optical imaging, the emerging second near-infrared (NIR-II) window optical imaging technology owns the great superiorities of non-invasiveness, non-ionizing radiation, and real-time dynamic imaging with the low biological interference, can significantly improve the tissue penetration depth and detection sensitivity, thus expecting to achieve accurate and precise diagnosis of major diseases. Inspired by the conspicuous superiorities, an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening diseases. Organic semiconducting nanomaterials (OSNs) are derived from organic conjugated molecules with π-electron delocalized skeletons, which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property, tunable energy bands, and fine biocompatibility. In this review, the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases, including tongue cancer, ovarian cancer, osteosarcoma, bacteria or pathogens infection, kidney dysfunction, rheumatoid arthritis, liver injury, and cerebrovascular function, are emphatically summarized. Finally, the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.


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About this article

Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging

Show Author's information Xiaoming Hu1,2, Fengwei Sun1, Caijun Zhu2, Zhen Yang1( ), Wei Huang1,3( )
Strait Laboratory of Flexible Electronics (SLoFE), Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University, Fuzhou 350117, China
Jiangxi Key Laboratory of Nanobiomaterials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China
Frontiers Science Center for Flexible Electronics (FSCFE), MIIT Key Laboratory of Flexible Electronics (KLoFE), Northwestern Polytechnical University, Xi’an 710072, China

Abstract

Optical imaging possesses important implications for early disease diagnosis, timely disease treatment, and basic medical as well as biological research. Compared with the traditionary near-infrared (NIR-I) window (650–950 nm) optical imaging, the emerging second near-infrared (NIR-II) window optical imaging technology owns the great superiorities of non-invasiveness, non-ionizing radiation, and real-time dynamic imaging with the low biological interference, can significantly improve the tissue penetration depth and detection sensitivity, thus expecting to achieve accurate and precise diagnosis of major diseases. Inspired by the conspicuous superiorities, an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening diseases. Organic semiconducting nanomaterials (OSNs) are derived from organic conjugated molecules with π-electron delocalized skeletons, which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property, tunable energy bands, and fine biocompatibility. In this review, the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases, including tongue cancer, ovarian cancer, osteosarcoma, bacteria or pathogens infection, kidney dysfunction, rheumatoid arthritis, liver injury, and cerebrovascular function, are emphatically summarized. Finally, the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.

Keywords: malignant tumor, infections, organic semiconducting nanomaterials, second near-infrared (NIR-II) fluorescence imaging, organic injury

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Publication history
Copyright
Acknowledgements

Publication history

Received: 10 September 2022
Revised: 29 September 2022
Accepted: 02 October 2022
Published: 05 December 2022
Issue date: April 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the Natural Science Foundation of Jiangxi Province (Nos. 20212BAB214005 and 20212ACB214002) and the Research startup fund of East China Jiaotong University (No. 465).

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