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Nano Research 2023, 16(2): 2885-2894 https://doi.org/10.1007/s12274-022-5032-9
Research Article | Issue | Published: 15 November 2022

Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism

Show Author's Information Lei Zhang1,§,  Jiaru Jing1,§,  Lin Han1,  Ziyan Liu1,  Jingyu Wang1,  Wei Zhang1,  Ai Gao1,2( )
Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China
Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China

§ Lei Zhang and Jiaru Jing contributed equally to this work.

Keywords:
melatonin, gut microbiota-metabolism, probiotics, nanoplastics exposure, hematopoietic injury
Topics:
Immune system
Cite this article:
Zhang L, Jing J, Han L, et al. Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism. Nano Research, 2023, 16(2): 2885-2894. https://doi.org/10.1007/s12274-022-5032-9
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Abstract Full text Electronic supplementary material About this article

Plastic pollution has become a non-negligible global pollution problem. Nanoplastics (NP) can reach the bone marrow with blood circulation and develop hematotoxicity, but potential mechanisms and prevention strategies are lacking. Here, we report the biological distribution of NP particles in the bone marrow of mice and hematopoietic toxicity after exposure to 60 µg of 80 nm NP for 42 days. NP exposure inhibited the capability of bone marrow hematopoietic stem cells to renew and differentiate. Notably, probiotics and melatonin supplementation significantly ameliorated NP-induced hematopoietic damage, and the former was superior to the latter. And interestingly, melatonin and probiotic interventions may involve different microbes and metabolites. After melatonin intervention, creatine showed a stronger correlation with NP-induced gut microbiota disorders. In contrast, probiotic intervention reversed the levels of more gut microbes and plasma metabolites. Of these, threonine, malonylcarnitine, and 3-hydroxybutyric acid might be potential performers in the regulation of hematopoietic toxicity by gut microbes, as they had a more significant relationship with the identified microbes. In conclusion, supplementation with melatonin or probiotics may be two candidates to prevent hematopoietic toxicity attributable to NP exposure. Also, the multi-omics results may lay the foundation for future investigations into in-depth mechanisms.


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Abstract
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Electronic supplementary material
About this article

Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism

Show Author's information Lei Zhang1,§, Jiaru Jing1,§, Lin Han1, Ziyan Liu1, Jingyu Wang1, Wei Zhang1, Ai Gao1,2( )
Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China
Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China

§ Lei Zhang and Jiaru Jing contributed equally to this work.

Abstract

Plastic pollution has become a non-negligible global pollution problem. Nanoplastics (NP) can reach the bone marrow with blood circulation and develop hematotoxicity, but potential mechanisms and prevention strategies are lacking. Here, we report the biological distribution of NP particles in the bone marrow of mice and hematopoietic toxicity after exposure to 60 µg of 80 nm NP for 42 days. NP exposure inhibited the capability of bone marrow hematopoietic stem cells to renew and differentiate. Notably, probiotics and melatonin supplementation significantly ameliorated NP-induced hematopoietic damage, and the former was superior to the latter. And interestingly, melatonin and probiotic interventions may involve different microbes and metabolites. After melatonin intervention, creatine showed a stronger correlation with NP-induced gut microbiota disorders. In contrast, probiotic intervention reversed the levels of more gut microbes and plasma metabolites. Of these, threonine, malonylcarnitine, and 3-hydroxybutyric acid might be potential performers in the regulation of hematopoietic toxicity by gut microbes, as they had a more significant relationship with the identified microbes. In conclusion, supplementation with melatonin or probiotics may be two candidates to prevent hematopoietic toxicity attributable to NP exposure. Also, the multi-omics results may lay the foundation for future investigations into in-depth mechanisms.

Keywords: melatonin, gut microbiota-metabolism, probiotics, nanoplastics exposure, hematopoietic injury

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Publication history
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Acknowledgements

Publication history

Received: 13 July 2022
Revised: 04 September 2022
Accepted: 09 September 2022
Published: 15 November 2022
Issue date: February 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This study was funded by the National Natural Science Foundation of China (Nos. 82073520 and 81773397), the Beijing Natural Science Program and Sci-entific Research Key Program of Beijing Municipal Commission of Ed-ucation (No. KZ201810025032), and the Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan (No. CIT&TCD 20170323).

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