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Review Article

Recent advances of bioresponsive polymeric nanomedicine for cancer therapy

Tu Hong1,§, Xinyuan Shen2,§, Madiha Zahra Syeda1,§, Yang Zhang2, Haonan Sheng2, Yipeng Zhou3, JinMing Xu4, Chaojie Zhu2,6, Hongjun Li2,5,6( ), Zhen Gu2,5,7,8,9( ), Longguang Tang1( )
International institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China
Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China
Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
Jinhua Institute of Zhejiang University, Jinhua 321299, China
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

§ Tu Hong, Xinyuan Shen, and Madiha Zahra Syeda contributed equally to this work.

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Abstract

A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes, and can exert its therapeutic efficacy within a confined space. These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues. Moreover, bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage. In this review, recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized. We mainly discuss three categories, including acidity-sensitive, redox-responsive, and enzyme-triggered polymeric nanosystems. The important issues regarding clinical translation such as reproducibility, manufacture, and probable toxicity, are also commented.

Graphical Abstract

Bioresponsive polymeric drug delivery platforms can improve drug loading and achieve various functions in response to the variances of the physicochemical properties between tumor tissues and normal tissues.

Keywords

drug deliverypolymerbioresponsiveimmunotherapycancer therapy

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Nano Research
Volume 16 Issue 2,
February 2023
Pages 2660-2671
DOI: 10.1007/s12274-022-5002-2

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Cite this article:
Hong T, Shen X, Syeda MZ, et al. Recent advances of bioresponsive polymeric nanomedicine for cancer therapy. Nano Research, 2023, 16(2): 2660-2671. https://doi.org/10.1007/s12274-022-5002-2
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Controlled drug delivery

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Received: 14 July 2022
Revised: 31 August 2022
Accepted: 01 September 2022
Published: 15 November 2022
© Tsinghua University Press 2022