FeS@LAB-35@Ti₃C₂ as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

The abuse of antibiotics leads to a significant increase in bacterial resistance, which makes it difficult to treat bacterial infections. Therefore, it is urgent to develop new strategies for efficient antibacterial and wound healing. Recently, nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency. In this study, we report a FeS@lauramidopropyl betaine (LAB-35)@Ti₃C₂ nanozyme as a high-efficiency antibacterial agent for near infrared (NIR) light induced photothermal enhanced chemodynamic antibacteria and wound healing. The FeS@LAB-35@Ti₃C₂ nanozyme possesses peroxidase-like catalysis activity, which can promote the generation of hydroxyl radicals (·OH) through catalyzing the decomposition of H₂O₂. FeS@LAB-35@Ti₃C₂ has photothermal conversion efficiency (η = 65.1%), and it exhibits enhanced catalytic activity under NIR light irradiation. The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti₃C₂ against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. The animal experiments indicate that FeS@LAB-35@Ti₃C₂ nanozyme can effectively inhibit wound ulceration and promote wound healing. Overall, this study proposes FeS@LAB-35@Ti₃C₂ nanozyme that integrates chemodynamic and photothermal therapy, which provides an efficient strategy for bacterial inhibition and wound healing.