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Nano Research 2023, 16(2): 2840-2850 https://doi.org/10.1007/s12274-022-4965-3
Research Article | Issue | Published: 03 October 2022

FeS@LAB-35@Ti3C2 as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

Show Author's Information Gaoqi Sun1,  Xuefeng Jiang1,  Cheng Liu2,  Saijie Song1( ),  Jun Zhang1( ),  Jian Shen1,3( )
National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
Medical School, Nanjing University, Nanjing 210093, China
Jiangsu Engineering Research Center of Interfacial Chemistry, Nanjing University, Nanjing 210023, China
Keywords:
MXene, wound healing, nanozyme, FeS, photothermal enhanced chemodynamic antibacterial activity
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Nano biology
Cite this article:
Sun G, Jiang X, Liu C, et al. FeS@LAB-35@Ti3C2 as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing. Nano Research, 2023, 16(2): 2840-2850. https://doi.org/10.1007/s12274-022-4965-3
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Abstract Full text Electronic supplementary material About this article

The abuse of antibiotics leads to a significant increase in bacterial resistance, which makes it difficult to treat bacterial infections. Therefore, it is urgent to develop new strategies for efficient antibacterial and wound healing. Recently, nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency. In this study, we report a FeS@lauramidopropyl betaine (LAB-35)@Ti3C2 nanozyme as a high-efficiency antibacterial agent for near infrared (NIR) light induced photothermal enhanced chemodynamic antibacteria and wound healing. The FeS@LAB-35@Ti3C2 nanozyme possesses peroxidase-like catalysis activity, which can promote the generation of hydroxyl radicals (·OH) through catalyzing the decomposition of H2O2. FeS@LAB-35@Ti3C2 has photothermal conversion efficiency (η = 65.1%), and it exhibits enhanced catalytic activity under NIR light irradiation. The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti3C2 against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. The animal experiments indicate that FeS@LAB-35@Ti3C2 nanozyme can effectively inhibit wound ulceration and promote wound healing. Overall, this study proposes FeS@LAB-35@Ti3C2 nanozyme that integrates chemodynamic and photothermal therapy, which provides an efficient strategy for bacterial inhibition and wound healing.


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Electronic supplementary material
About this article

FeS@LAB-35@Ti3C2 as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

Show Author's information Gaoqi Sun1, Xuefeng Jiang1, Cheng Liu2, Saijie Song1( ), Jun Zhang1( ), Jian Shen1,3( )
National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
Medical School, Nanjing University, Nanjing 210093, China
Jiangsu Engineering Research Center of Interfacial Chemistry, Nanjing University, Nanjing 210023, China

Abstract

The abuse of antibiotics leads to a significant increase in bacterial resistance, which makes it difficult to treat bacterial infections. Therefore, it is urgent to develop new strategies for efficient antibacterial and wound healing. Recently, nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency. In this study, we report a FeS@lauramidopropyl betaine (LAB-35)@Ti3C2 nanozyme as a high-efficiency antibacterial agent for near infrared (NIR) light induced photothermal enhanced chemodynamic antibacteria and wound healing. The FeS@LAB-35@Ti3C2 nanozyme possesses peroxidase-like catalysis activity, which can promote the generation of hydroxyl radicals (·OH) through catalyzing the decomposition of H2O2. FeS@LAB-35@Ti3C2 has photothermal conversion efficiency (η = 65.1%), and it exhibits enhanced catalytic activity under NIR light irradiation. The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti3C2 against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. The animal experiments indicate that FeS@LAB-35@Ti3C2 nanozyme can effectively inhibit wound ulceration and promote wound healing. Overall, this study proposes FeS@LAB-35@Ti3C2 nanozyme that integrates chemodynamic and photothermal therapy, which provides an efficient strategy for bacterial inhibition and wound healing.

Keywords: MXene, wound healing, nanozyme, FeS, photothermal enhanced chemodynamic antibacterial activity

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Publication history
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Acknowledgements

Publication history

Received: 18 July 2022
Revised: 25 August 2022
Accepted: 25 August 2022
Published: 03 October 2022
Issue date: February 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the Jiangsu Province Science and Technology Support Plan (No. BE2019391) and the Jiangsu Collaborative Innovation Center of Biomedical Functional Materials.

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