Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma

Xiao Pan; Antian Gao; Yanni Hu; Ziyang Hu; Chen Xie; Zitong Lin

doi:10.1007/s12274-022-4947-5

Nano Research 2023, 16(2): 2808-2820 https://doi.org/10.1007/s12274-022-4947-5

Research Article | Issue | Published: 14 October 2022

Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma

Show Author's Information Hide Author's Information Xiao Pan^{¹^,^§}, Antian Gao^{¹^,^§}, Yanni Hu^¹, Ziyang Hu^¹, Chen Xie^²(

), Zitong Lin^¹(

)

1Department of Dentomaxillofacial Radiology, Affiliated Stomatology Hospital of Medical School, Nanjing University, Nanjing 210008, China

2Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China

^§ Xiao Pan and Antian Gao contributed equally to this work.

Keywords:

magnetic resonance imaging, fluorescence imaging, photothermal therapy, oral squamous cell carcinoma, dual-modal imaging, semiconducting polymer nanoparticles

Topics:

Fluorescence imaging Imaging technique Magnetic resonance imaging Molecular imaging Nanocomposites Tumors

Cite this article:

Pan X, Gao A, Hu Y, et al. Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma. Nano Research, 2023, 16(2): 2808-2820. https://doi.org/10.1007/s12274-022-4947-5

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Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral and maxillofacial region. Due to its unique location, earlier and more accurate diagnosis and more minimally invasive treatment of OSCC is of major importance. Herein, gadolinium-containing semiconductor polymer nanoparticles (SPN-Gd) were designed and prepared. The nanoparticles consist of a near-infrared (NIR) absorption semiconductor polymer (PCPDTBT) served as fluorescence signal source and a photothermal conversion agent (PTA) and a gadolinium-grafted triblock amphiphilic copolymer (F127-DTPA-Gd) served as a magnetic resonance imaging (MRI) contrast agent and nanocarrier. The experiments in vivo showed that SPN-Gd could act as an MRI contrast agent and optical image agent with a long retention time, and it had a significant inhibiting effect on tumors of OSCC mice model through photothermal therapy (PTT). Thus our study provides a simple nanotheranostic platform composed of two components for efficient MR/fluorescence dual-modal imaging-guided PTT.

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Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma

Show Author's information Hide Author's Information Xiao Pan^{¹^,^§}, Antian Gao^{¹^,^§}, Yanni Hu^¹, Ziyang Hu^¹, Chen Xie^²(

), Zitong Lin^¹(

)

1Department of Dentomaxillofacial Radiology, Affiliated Stomatology Hospital of Medical School, Nanjing University, Nanjing 210008, China

^§ Xiao Pan and Antian Gao contributed equally to this work.

Abstract

Keywords: magnetic resonance imaging, fluorescence imaging, photothermal therapy, oral squamous cell carcinoma, dual-modal imaging, semiconducting polymer nanoparticles

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Publication history

Acknowledgements

Publication history

Received: 22 June 2022

Revised: 22 August 2022

Accepted: 23 August 2022

Published: 14 October 2022

Issue date: February 2023

Copyright

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 82201135, 22174070, and 61905122), Nanjing Clinical Research Center for Oral Diseases (No. 2019060009), General project of Jiangsu Provincial Health Commission (No. M2021077), Scientific research fund of Jiangsu Medical Association (No. SYH-3201150-0007(2021002)), and the Natural Science Foundation of Jiangsu Province (No. BK20190735).