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Nano Research 2023, 16(2): 2798-2807 https://doi.org/10.1007/s12274-022-4936-8
Research Article | Issue | Published: 21 October 2022

Natural biopolymers derived hydrogels with injectable, self-healing, and tissue adhesive abilities for wound healing

Show Author's Information Bin Kong1,2,  Rui Liu1,  Yi Cheng1,  Xiaodong Cai2,  Junying Liu2,  Dagan Zhang1( ),  Hui Tan2( ),  Yuanjin Zhao1,3( )
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China
Respiratory department, Shenzhen Children's Hospital, Shenzhen 518038, China
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
Keywords:
hydrogel, wound healing, self-healing, tissue adhesive, injectability
Topics:
Biomaterials
Cite this article:
Kong B, Liu R, Cheng Y, et al. Natural biopolymers derived hydrogels with injectable, self-healing, and tissue adhesive abilities for wound healing. Nano Research, 2023, 16(2): 2798-2807. https://doi.org/10.1007/s12274-022-4936-8
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Abstract Full text Electronic supplementary material About this article

Developing a biocompatible and multifunctional adhesive hydrogel with injectability and self-healing ability for promoting wound healing is highly anticipated in various clinical applications. In this paper, we present a novel natural biopolymer-derived hydrogel based on the aldehyde-modified oxidized guar gum (OGG) and the carboxymethyl chitosan (CMCS) for efficiently improving wound healing with the encapsulation of vascular endothelial growth factor (VEGF). As the hydrogels are synthesized via the dynamically reversible Schiff base linkages, it is imparted with excellent self-healing ability and good shear thinning behavior, which make the hydrogel be easily and conveniently injected through a needle. Besides, the physiochemical properties, including porous structure, mechanical strength and swelling ratio of the hydrogel can be well controlled by regulating the concentrations of the OGG. Moreover, the hydrogel can attain strong adhesion to the tissues at physiological temperature based on the Schiff base between the aldehyde group on the hydrogel and the amino group on the tissue. Based on these features, we have demonstrated that the VEGF encapsulated hydrogel can adhere tightly to the defect tissue and improve wound repair in the rat model of defected skin by promoting cell proliferation, angiogenesis, and collagen secretion. These results indicate that the multifunctional hydrogel is with great scientific significance and broad clinical application prospects.


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Electronic supplementary material
About this article

Natural biopolymers derived hydrogels with injectable, self-healing, and tissue adhesive abilities for wound healing

Show Author's information Bin Kong1,2, Rui Liu1, Yi Cheng1, Xiaodong Cai2, Junying Liu2, Dagan Zhang1( ), Hui Tan2( ), Yuanjin Zhao1,3( )
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China
Respiratory department, Shenzhen Children's Hospital, Shenzhen 518038, China
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China

Abstract

Developing a biocompatible and multifunctional adhesive hydrogel with injectability and self-healing ability for promoting wound healing is highly anticipated in various clinical applications. In this paper, we present a novel natural biopolymer-derived hydrogel based on the aldehyde-modified oxidized guar gum (OGG) and the carboxymethyl chitosan (CMCS) for efficiently improving wound healing with the encapsulation of vascular endothelial growth factor (VEGF). As the hydrogels are synthesized via the dynamically reversible Schiff base linkages, it is imparted with excellent self-healing ability and good shear thinning behavior, which make the hydrogel be easily and conveniently injected through a needle. Besides, the physiochemical properties, including porous structure, mechanical strength and swelling ratio of the hydrogel can be well controlled by regulating the concentrations of the OGG. Moreover, the hydrogel can attain strong adhesion to the tissues at physiological temperature based on the Schiff base between the aldehyde group on the hydrogel and the amino group on the tissue. Based on these features, we have demonstrated that the VEGF encapsulated hydrogel can adhere tightly to the defect tissue and improve wound repair in the rat model of defected skin by promoting cell proliferation, angiogenesis, and collagen secretion. These results indicate that the multifunctional hydrogel is with great scientific significance and broad clinical application prospects.

Keywords: hydrogel, wound healing, self-healing, tissue adhesive, injectability

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Publication history
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Acknowledgements

Publication history

Received: 23 June 2022
Revised: 15 August 2022
Accepted: 18 August 2022
Published: 21 October 2022
Issue date: February 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 82101184 and 82102511), the Shenzhen Fundamental Research Program (Nos. JCYJ20210324102809024, JCYJ20190813152616459 and JCYJ20210324133214038), the Shenzhen PhD Start-up Program (Nos. RCBS20210609103713045, ZDSYS20200811142600003，JCYJ20180228162928828，and JCYJ20190806161409092), the Natural Science Foundation of Guangdong Province (No. 2020A1515110780), the Guangdong Basic and Applied Basic Research Foundation (No. 2021B1515120054), the Natural Science Foundation of Jiangsu (No. BK20210021), and the Research Project of Jiangsu Province Health Committee (No. M2021031).

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