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CSCD
A large amount of progress has achieved in neuroscience, however, there is still a lack of reasonable model for the storage/output (S/O) of life information. The cyclical motion of cardio- and pulmonary-myocyte is a typical process of the life information S/O, while the opening and closing sites of Ca2+ ion channels during the motion can form a genetically programmed time-dependent three-dimensional (3D) pattern. Those phenomena indicate a strong correlation of the information S/O model of these myocytes with the time-sequence 3D patterns. Therefore, based on the time-dependent Ca2+ fluorescence imaging during the motion of cardio- and pulmonary-myocyte, here we suggest a four-dimensional (4D) code of information S/O model in cell and nervous system. Further from the fact of pulmonary myocyte motion able to be controlled by brain, it is deduced that the 4D code in brain has a role of controlling muscles through a pathway of the central nervous system, peripheral nervous system, neuromuscular junction, and muscle cells. In addition, we also suggested the 4D code of non-innate skill that can be programmed by the learning/training of a long time (~ 3 years), such as walking, writing, painting, sports, speech, singing, and dancing. Noticeably, this 4D S/O model is reasonable for the ultralow energy consumption of life information transmission.
We thank very much for the fruitful discussions with Profs. Yousheng Shu, Liping Wang, and Markus Antonietti, Drs. Ye Yin and Jian Wang, as well as the video data of cardiomyocyte beating provided by Prof. Dong Han. This work was supported by the National Key R&D Program of China (Nos. 2021YFA1200404 and 2018YFA0208502) and the National Natural Science Foundation of China (Nos. 51973227, 21988102, and T224100002).