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Nano Research 2023, 16(2): 2049-2058 https://doi.org/10.1007/s12274-022-4876-5
Research Article | Issue | Published: 27 September 2022

Engineering Janus gold nanorod–titania heterostructures with enhanced photocatalytic antibacterial activity against multidrug-resistant bacterial infection

Show Author's Information Shuqin Li1,§,  Hongqi Huo2,§,  Xing Gao1,  Luntao Liu3( ),  Shumin Wang4,  Jiamin Ye2,  Jing Mu4( ),  Jibin Song2( )
School of Chemical and Biological Engineering, Qilu Institute of Technology, Jinan 250200, China
Department of Nuclear Medicine, Han Dan Central Hospital, Handan 056001, China
Ministry of Education (MOE) Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, China
Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China

§ Shuqin Li and Hongqi Huo contributed equally to this work.

Keywords:
wound healing, photocatalytic antibacterial, Janus gold nanorod-titanium dioxide nanoparticles (Janus AuNR-TiO2 NPs), multidrug resistant bacterial infection
Topics:
Photocatalysts
Cite this article:
Li S, Huo H, Gao X, et al. Engineering Janus gold nanorod–titania heterostructures with enhanced photocatalytic antibacterial activity against multidrug-resistant bacterial infection. Nano Research, 2023, 16(2): 2049-2058. https://doi.org/10.1007/s12274-022-4876-5
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Abstract Full text Electronic supplementary material About this article

Photocatalytic antibacterial approach shows great potential in treating multidrug-resistant bacterial infections. However, the bactericidal efficiency heavily depends on the photocatalytic activity of semiconductor materials, which is limited by the fast recombination of photogenerated electron–hole pairs. Janus nano-heterostructures with spatial control growth of TiO2 nanoparticles (NPs) at one end of gold nanorods (Au NRs) are designed via surface ligand regulation for photocatalytic sterilization and infected wound healing. The asymmetric nanostructure of Janus gold nanorod-titanium dioxide nanoparticles (Janus AuNR-TiO2 NPs) promotes the directional migration of charge carriers and is more conducive to the spatial separation of electron–hole pairs. Moreover, the injection of hot electrons and enhancement of plasmon near-fields from the surface plasmon resonance (SPR) effect further improve the photocatalytic efficiency of Janus AuNR-TiO2 NPs. Under simulated sunlight irradiation, large amounts of reactive oxygen species (ROS) are generated for photocatalytic antibacterial activity. Enhanced bactericidal efficiency up to 99.99% against methicillin-resistant Staphylococcus aureus (MRSA) is achieved in vitro. Furthermore, Janus AuNR-TiO2 NPs exhibit superior biocompatibility, structural stability, and also remarkably accelerate MRSA-infected wound healing. Taking the above all into consideration, Janus AuNR-TiO2 NPs, as an efficient antibacterial photocatalyst, offers a promising strategy for MRSA infectious therapy.


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Electronic supplementary material
About this article

Engineering Janus gold nanorod–titania heterostructures with enhanced photocatalytic antibacterial activity against multidrug-resistant bacterial infection

Show Author's information Shuqin Li1,§, Hongqi Huo2,§, Xing Gao1, Luntao Liu3( ), Shumin Wang4, Jiamin Ye2, Jing Mu4( ), Jibin Song2( )
School of Chemical and Biological Engineering, Qilu Institute of Technology, Jinan 250200, China
Department of Nuclear Medicine, Han Dan Central Hospital, Handan 056001, China
Ministry of Education (MOE) Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, China
Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China

§ Shuqin Li and Hongqi Huo contributed equally to this work.

Abstract

Photocatalytic antibacterial approach shows great potential in treating multidrug-resistant bacterial infections. However, the bactericidal efficiency heavily depends on the photocatalytic activity of semiconductor materials, which is limited by the fast recombination of photogenerated electron–hole pairs. Janus nano-heterostructures with spatial control growth of TiO2 nanoparticles (NPs) at one end of gold nanorods (Au NRs) are designed via surface ligand regulation for photocatalytic sterilization and infected wound healing. The asymmetric nanostructure of Janus gold nanorod-titanium dioxide nanoparticles (Janus AuNR-TiO2 NPs) promotes the directional migration of charge carriers and is more conducive to the spatial separation of electron–hole pairs. Moreover, the injection of hot electrons and enhancement of plasmon near-fields from the surface plasmon resonance (SPR) effect further improve the photocatalytic efficiency of Janus AuNR-TiO2 NPs. Under simulated sunlight irradiation, large amounts of reactive oxygen species (ROS) are generated for photocatalytic antibacterial activity. Enhanced bactericidal efficiency up to 99.99% against methicillin-resistant Staphylococcus aureus (MRSA) is achieved in vitro. Furthermore, Janus AuNR-TiO2 NPs exhibit superior biocompatibility, structural stability, and also remarkably accelerate MRSA-infected wound healing. Taking the above all into consideration, Janus AuNR-TiO2 NPs, as an efficient antibacterial photocatalyst, offers a promising strategy for MRSA infectious therapy.

Keywords: wound healing, photocatalytic antibacterial, Janus gold nanorod-titanium dioxide nanoparticles (Janus AuNR-TiO2 NPs), multidrug resistant bacterial infection

References(43)

[1]

Nguyen, V. N.; Zhao, Z.; Tang, B. Z.; Yoon, J. Organic photosensitizers for antimicrobial phototherapy. Chem. Soc. Rev. 2022, 51, 3324–3340.
DOI Google Scholar
[2]

Tang, N.; Zhang, R. J.; Zheng, Y. B.; Wang, J.; Khatib, M.; Jiang, X.; Zhou, C.; Omar, R.; Saliba, W.; Wu, W. W. et al. Highly efficient self-healing multifunctional dressing with antibacterial activity for sutureless wound closure and infected wound monitoring. Adv. Mater. 2022, 34, 2270025.
DOI Google Scholar
[3]

Chen, M.; Winston, D. D.; Wang, M.; Niu, W.; Cheng, W.; Guo, Y.; Wang, Y. D.; Luo, M.; Xie, C. X.; Leng, T. T. et al. Hierarchically multifunctional bioactive nanoglass for integrated tumor/infection therapy and impaired wound repair. Mater. Today 2022, 53, 27–40.
DOI Google Scholar
[4]

Zhou, B. S.; Sun, X. L.; Dong, B.; Yu, S. Y.; Cheng, L.; Hu, S. T.; Liu, W.; Xu, L.; Bai, X.; Wang, L. et al. Antibacterial PDT nanoplatform capable of releasing therapeutic gas for synergistic and enhanced treatment against deep infections. Theranostics 2022, 12, 2580–2597.
DOI Google Scholar
[5]

Wang, Z. Q.; Koirala, B.; Hernandez, Y.; Zimmerman, M.; Park, S.; Perlin, D. S.; Brady, S. F. A naturally inspired antibiotic to target multidrug-resistant pathogens. Nature 2022, 601, 606–611.
DOI Google Scholar
[6]

Sun, D.; Pang, X.; Cheng, Y.; Ming, J.; Xiang, S. J.; Zhang, C.; Lv, P.; Chu, C. C.; Chen, X. L.; Liu, G. et al. Ultrasound-switchable nanozyme augments sonodynamic therapy against multidrug-resistant bacterial infection. ACS Nano 2020, 14, 2063–2076.
DOI Google Scholar
[7]

Zeng, J. Y.; Guo, Z. C.; Wang, Y. H.; Qin, Z. J.; Ma, Y.; Jiang, H.; Weizmann, Y.; Wang, X. M. Intelligent bio-assembly imaging-guided platform for real-time bacteria sterilizing and infectious therapy. Nano Res. 2022, 15, 4164–4174.
DOI Google Scholar
[8]

Stracy, M.; Snitser, O.; Yelin, I.; Amer, Y.; Parizade, M.; Katz, R.; Rimler, G.; Wolf, T.; Herzel, E.; Koren, G. et al. Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections. Science 2022, 375, 889–894.
DOI Google Scholar
[9]

Ma, L. M.; Xie, X.; Liu, H. H.; Huang, Y.; Wu, H. M.; Jiang, M. L.; Xu, P. F.; Ye, X. Y.; Zhou, C. L. Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria. Theranostics 2020, 10, 1373–1390.
DOI Google Scholar
[10]

Pan, X. T.; Wu, N. E.; Tian, S. Y.; Guo, J.; Wang, C. H.; Sun, Y.; Huang, Z. Z.; Chen, F. Z.; Wu, Q. Y.; Jing, Y. et al. Inhalable MOF-derived nanoparticles for sonodynamic therapy of bacterial pneumonia. Adv. Funct. Mater. 2022, 32, 2112145.
DOI Google Scholar
[11]

Chen, L. F.; Xing, S. H.; Lei, Y. L.; Chen, Q. S.; Zou, Z.; Quan, K.; Qing, Z.; Liu, J. W.; Yang, R. H. A glucose-powered activatable nanozyme breaking pH and H2O2 limitations for treating diabetic infections. Angew. Chem., Int. Ed. 2021, 60, 23534–23539.
DOI Google Scholar
[12]

Li, J. F.; Li, Z. Y.; Liu, X. M.; Li, C. Y.; Zheng, Y. F.; Yeung, K. W. K.; Cui, Z. D.; Liang, Y. Q.; Zhu, S. L.; Hu, W. B. et al. Interfacial engineering of Bi2S3/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing. Nat. Commun. 2021, 12, 1224.
DOI Google Scholar
[13]

Malysheva, A.; Ivask, A.; Doolette, C. L.; Voelcker, N. H.; Lombi, E. Cellular binding, uptake and biotransformation of silver nanoparticles in human T lymphocytes. Nat. Nanotechnol. 2021, 16, 926–932.
DOI Google Scholar
[14]

Wu, M. Q.; Zhang, Z. Y.; Liu, Z. R.; Zhang, J. M.; Zhang, Y. L.; Ding, Y. M.; Huang, T.; Xiang, D. L.; Wang, Z.; Dai, Y. J. et al. Piezoelectric nanocomposites for sonodynamic bacterial elimination and wound healing. Nano Today 2021, 37, 101104.
DOI Google Scholar
[15]

Matsunaga, T.; Tomoda, R.; Nakajima, T.; Wake, H. Photoelectrochemical sterilization of microbial cells by semiconductor powders. FEMS Microbiol. Lett. 1985, 29, 211–214.
DOI Google Scholar
[16]

Wang, J. J.; Wang, Y.; Wang, W.; Peng, T.; Liang, J. J.; Li, P.; Pan, D. Q.; Fan, Q. H.; Wu, W. S. Visible light driven Ti3+ self-doped TiO2 for adsorption–photocatalysis of aqueous U(VI). Environ. Pollut. 2020, 262, 114373.
DOI Google Scholar
[17]

Duan, S.; Wu, R. N.; Xiong, Y. H.; Ren, H. M.; Lei, C. Y.; Zhao, Y. Q.; Zhang, X. Y.; Xu, F. J. Multifunctional antimicrobial materials: From rational design to biomedical applications. Prog. Mater. Sci. 2022, 125, 100887.
DOI Google Scholar
[18]

Wang, D.; Wang, H. Z.; Ji, L.; Xu, M.; Bai, B.; Wan, X. D.; Hou, D. Y.; Qiao, Z. Y.; Wang, H.; Zhang, J. T. Hybrid plasmonic nanodumbbells engineering for multi-intensified second near-infrared light induced photodynamic therapy. ACS Nano. 2021, 15, 8694–8705.
DOI Google Scholar
[19]

Zeng, J. Y.; Li, Z. M.; Jiang, H.; Wang, X. M. Progress on photocatalytic semiconductor hybrids for bacterial inactivation. Mater. Horiz. 2021, 8, 2964–3008.
DOI Google Scholar
[20]

Li, L.; Cao, S. J.; Wu, Z. H.; Guo, R. Q.; Xie, L.; Wang, L. Y.; Tang, Y. J.; Li, Q.; Luo, X. L.; Ma, L. et al. Modulating electron transfer in vanadium-based artificial enzymes for enhanced ROS-catalysis and disinfection. Adv. Mater. 2022, 34, 2108646.
DOI Google Scholar
[21]

Tu, Y. S.; Li, P.; Sun, J. J.; Jiang, J.; Dai, F. F.; Li, C. Z.; Wu, Y. Y.; Chen, L.; Shi, G. S.; Tan, Y. W. et al. Remarkable antibacterial activity of reduced graphene oxide functionalized by copper ions. Adv. Funct. Mater. 2021, 31, 2008018.
DOI Google Scholar
[22]

Yang, M. G.; Qiu, S.; Coy, E.; Li, S. J.; Załęski, K.; Zhang, Y.; Pan, H. B.; Wang, G. C. NIR-responsive TiO2 biometasurfaces: Toward in situ photodynamic antibacterial therapy for biomedical implants. Adv. Mater. 2022, 34, 2106314.
DOI Google Scholar
[23]

Zeng, X. K.; Wang, Z. Y.; Wang, G.; Gengenbach, T. R.; McCarthy, D. T.; Deletic, A.; Yu, J. G.; Zhang, X. W. Highly dispersed TiO2 nanocrystals and WO3 nanorods on reduced graphene oxide: Z-scheme photocatalysis system for accelerated photocatalytic water disinfection. Appl. Catal. B: Environ. 2017, 218, 163–173.
DOI Google Scholar
[24]

Xia, P. F.; Cao, S. W.; Zhu, B. C.; Liu, M. J.; Shi, M. S.; Yu, J. G.; Zhang, Y. F. Designing a 0D/2D S-scheme heterojunction over polymeric carbon nitride for visible-light photocatalytic inactivation of bacteria. Angew. Chem., Int. Ed. 2020, 59, 5218–5225.
DOI Google Scholar
[25]

Li, X. Y.; Sun, H. B.; Xie, Y. Y.; Liang, Y. S.; Gong, X. M.; Qin, P. F.; Jiang, L. B.; Guo, J. Y.; Liu, C.; Wu, Z. B. Principles, synthesis and applications of dual Z-scheme photocatalysts. Coord. Chem. Rev. 2022, 467, 214596.
DOI Google Scholar
[26]

Liu, Y. W.; Cullen, D. A.; Lian, T. Q. Slow auger recombination of trapped excitons enables efficient multiple electron transfer in CdS-Pt nanorod heterostructures. J. Am. Chem. Soc. 2021, 143, 20264–20273.
DOI Google Scholar
[27]

Gudjonsdottir, S.; Van Der Stam, W.; Kirkwood, N.; Evers, W. H.; Houtepen, A. J. The role of dopant ions on charge injection and transport in electrochemically doped quantum dot films. J. Am. Chem. Soc. 2018, 140, 6582–6590.
DOI Google Scholar
[28]

Gong, S. Q.; Niu, Y. L.; Teng, X.; Liu, X.; Xu, M. Z.; Xu, C.; Meyer, T. J.; Chen, Z. F. Visible light-driven, selective CO2 reduction in water by in-doped Mo2C based on defect engineering. Appl. Catal. B:Environ. 2022, 310, 121333.
DOI Google Scholar
[29]

Zhou, D. X.; Xue, X. D.; Wang, X.; Luan, Q. J.; Li, A.; Zhang, L. G.; Li, B. Z.; Dong, W. J.; Wang, G.; Hou, C. M. Ni, In co-doped ZnIn2S4 for efficient hydrogen evolution: Modulating charge flow and balancing H adsorption/desorption. Appl. Catal. B: Environ. 2022, 310, 121337.
DOI Google Scholar
[30]

Zhao, J. M.; Liu, L. T.; Zhang, Y.; Feng, Z. Y.; Zhao, F. F.; Wang, W. S. Light-responsive color switching of self-doped TiO2−x/WO3·0.33H2O hetero-nanoparticles for highly efficient rewritable paper. Nano Res. 2021, 14, 165–171.
DOI Google Scholar
[31]

Tian, N.; Hu, C.; Wang, J. J.; Zhang, Y. H.; Ma, T. Y.; Huang, H. W. Layered bismuth-based photocatalysts. Coord. Chem. Rev. 2022, 463, 214515.
DOI Google Scholar
[32]

Liao, G. F.; Tao, X. Y.; Fang, B. Z. An innovative synthesis strategy for high-efficiency and defects-switchable-hydrogenated TiO2 photocatalysts. Matter 2022, 5, 377–379.
DOI Google Scholar
[33]

Wang, T.; Chen, L.; Chen, C.; Huang, M. T.; Huang, Y. J.; Liu, S. J.; Li, B. X. Engineering catalytic interfaces in Cuδ+/CeO2-TiO2 photocatalysts for synergistically boosting CO2 reduction to ethylene. ACS Nano 2022, 16, 2306–2318.
DOI Google Scholar
[34]

Huang, H. W.; Verhaeghe, D.; Weng, B.; Ghosh, B.; Zhang, H. W.; Hofkens, J.; Steele, J. A.; Roeffaers, M. B. J. Metal halide perovskite based heterojunction photocatalysts. Angew. Chem., Int. Ed. 2022, 61, e202203261.
DOI Google Scholar
[35]

Torras, M.; Molet, P.; Soler, L.; Llorca, J.; Roig, A.; Mihi, A. Au/TiO2 2D-photonic crystals as UV–visible photocatalysts for H2 production. Adv. Energy Mater. 2022, 12, 2103733.
DOI Google Scholar
[36]

Lu, Z. X.; Wu, X.; Chen, N. Y.; Cao, M. F.; Sartin, M. M.; Ren, B. Photoinduced charge transfer from a semiconductor to a metal probed at the single-nanoparticle level. ACS Energy Lett. 2021, 6, 3473–3480.
DOI Google Scholar
[37]

Khan, R.; Naveen, M. H.; Abbas, M. A.; Lee, J.; Kim, H.; Bang, J. H. Photoelectrochemistry of Au nanocluster-sensitized TiO2: Intricacy arising from the light-induced transformation of nanoclusters into nanoparticles. ACS Energy Lett. 2021, 6, 24–32.
DOI Google Scholar
[38]

Seh, Z. W.; Liu, S. H.; Low, M.; Zhang, S. Y.; Liu, Z. L.; Mlayah, A.; Han, M. Y. Janus Au-TiO2 photocatalysts with strong localization of plasmonic near-fields for efficient visible-light hydrogen generation. Adv. Mater. 2012, 24, 2310–2314.
DOI Google Scholar
[39]

Cai, R.; Xiang, H. D.; Yang, D.; Lin, K. T.; Wu, Y. Z.; Zhou, R. Y.; Gu, Z. J.; Yan, L.; Zhao, Y. L.; Tan, W. H. Plasmonic AuPt@CuS heterostructure with enhanced synergistic efficacy for radiophotothermal therapy. J. Am. Chem. Soc. 2021, 143, 16113–16127.
DOI Google Scholar
[40]

Liang, S.; Deng, X. R.; Chang, Y.; Sun, C. Q.; Shao, S.; Xie, Z. X.; Xiao, X.; Ma, P.; Zhang, H. Y.; Cheng, Z. Y. et al. Intelligent hollow Pt-CuS Janus architecture for synergistic catalysis-enhanced sonodynamic and photothermal cancer therapy. Nano Lett. 2019, 19, 4134–4145.
DOI Google Scholar
[41]

Ben-Shahar, Y.; Philbin, J. P.; Scotognella, F.; Ganzer, L.; Cerullo, G.; Rabani, E.; Banin, U. Charge carrier dynamics in photocatalytic hybrid semiconductor-metal nanorods: Crossover from auger recombination to charge transfer. Nano Lett. 2018, 18, 5211–5216.
DOI Google Scholar
[42]

Vigderman, L.; Zubarev, E. R. High-yield synthesis of gold nanorods with longitudinal SPR peak greater than 1,200 nm using hydroquinone as a reducing agent. Chem. Mater. 2013, 25, 1450–1457.
DOI Google Scholar
[43]

Chen, T.; Chen, G.; Xing, S. X.; Wu, T.; Chen, H. Y. Scalable routes to Janus Au-SiO2 and ternary Ag-Au-SiO2 nanoparticles. Chem. Mater. 2010, 22, 3826–3828.
DOI Google Scholar
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Publication history
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Acknowledgements

Publication history

Received: 29 June 2022
Revised: 02 August 2022
Accepted: 06 August 2022
Published: 27 September 2022
Issue date: February 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This research was supported by the National Natural Science Foundation of China (Nos. 21874024, 32101074, and U21A20377), the Joint Research Program of Health and Education Commission of Fujian Province (No. 2019-WJ-20), and the Natural Science Foundation of Fujian Province (No. 2020J02012).

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