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Research Article

Ultra-bright near-infrared-IIb emitting Zn-doped Ag2Te quantum dots for noninvasive monitoring of traumatic brain injury

Yifei Zhou1,§, Biao Huang1,§, Shi-Hui Chen1, Shu-Lin Liu3, Mingxi Zhang2( ), Ran Cui1( )
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China

§ Yifei Zhou and Biao Huang contributed equally to this work.

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Abstract

The long-wavelength region of the near-infrared-IIb (NIR-IIb, 1,500–1,700 nm) imaging window has become an ideal window for in vivo imaging due to the suppressed photon scattering and near-zero autofluorescence of biological tissues. Therefore, it is necessary to develop fluorescent probes with excellent fluorescence performance and stability for NIR-IIb fluorescence imaging. In this work, zinc-doped silver telluride quantum dots (Zn:Ag2Te QDs) with bright fluorescence in the NIR-IIb window were synthesized. The introduction of Zn dopants inhibited crystal defects and reduced non-radiative transitions. Therefore, the quantum yield and fluorescence lifetime of Zn:Ag2Te QDs were significantly improved. In addition, Zn-doping increased the number of ligands on the surface of QDs, thus enhancing the colloidal stability of Zn:Ag2Te QDs. Moreover, the PEGylated Zn:Ag2Te QDs with high absolute quantum yield realized noninvasive imaging of cerebral vascular of mouse with high resolution able to distinguish blood capillary, which could be utilized to monitor the brain condition of mice after traumatic brain injury.

Graphical Abstract

The introduction of Zn dopants significantly improves the fluorescent performance and colloidal stability of Ag2Te quantum dots (QDs) emitting in the near-infrared-IIb window (1,500–1,700 nm), thus realizing noninvasive monitoring of mouse brain after traumatic brain injury with high resolution.

Keywords

near-infrared-IIb (NIR-IIb) windowsilver telluridequantum dotsfluorescencein vivo imaging

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Nano Research
Volume 16 Issue 2,
February 2023
Pages 2719-2727
DOI: 10.1007/s12274-022-4875-6

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Cite this article:
Zhou Y, Huang B, Chen S-H, et al. Ultra-bright near-infrared-IIb emitting Zn-doped Ag2Te quantum dots for noninvasive monitoring of traumatic brain injury. Nano Research, 2023, 16(2): 2719-2727. https://doi.org/10.1007/s12274-022-4875-6
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Received: 21 June 2022
Revised: 05 August 2022
Accepted: 06 August 2022
Published: 10 September 2022
© Tsinghua University Press 2022