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Nano Research 2023, 16(2): 2719-2727 https://doi.org/10.1007/s12274-022-4875-6
Research Article | Issue | Published: 10 September 2022

Ultra-bright near-infrared-IIb emitting Zn-doped Ag2Te quantum dots for noninvasive monitoring of traumatic brain injury

Show Author's Information Yifei Zhou1,§,  Biao Huang1,§,  Shi-Hui Chen1,  Shu-Lin Liu3,  Mingxi Zhang2( ),  Ran Cui1( )
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China

§ Yifei Zhou and Biao Huang contributed equally to this work.

Keywords:
quantum dots, fluorescence, in vivo imaging, near-infrared-IIb (NIR-IIb) window, silver telluride
Topics:
Nanoprobes
Cite this article:
Zhou Y, Huang B, Chen S-H, et al. Ultra-bright near-infrared-IIb emitting Zn-doped Ag2Te quantum dots for noninvasive monitoring of traumatic brain injury. Nano Research, 2023, 16(2): 2719-2727. https://doi.org/10.1007/s12274-022-4875-6
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Abstract Electronic supplementary material About this article

The long-wavelength region of the near-infrared-IIb (NIR-IIb, 1,500–1,700 nm) imaging window has become an ideal window for in vivo imaging due to the suppressed photon scattering and near-zero autofluorescence of biological tissues. Therefore, it is necessary to develop fluorescent probes with excellent fluorescence performance and stability for NIR-IIb fluorescence imaging. In this work, zinc-doped silver telluride quantum dots (Zn:Ag2Te QDs) with bright fluorescence in the NIR-IIb window were synthesized. The introduction of Zn dopants inhibited crystal defects and reduced non-radiative transitions. Therefore, the quantum yield and fluorescence lifetime of Zn:Ag2Te QDs were significantly improved. In addition, Zn-doping increased the number of ligands on the surface of QDs, thus enhancing the colloidal stability of Zn:Ag2Te QDs. Moreover, the PEGylated Zn:Ag2Te QDs with high absolute quantum yield realized noninvasive imaging of cerebral vascular of mouse with high resolution able to distinguish blood capillary, which could be utilized to monitor the brain condition of mice after traumatic brain injury.

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Publication history
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Acknowledgements

Publication history

Received: 21 June 2022
Revised: 05 August 2022
Accepted: 06 August 2022
Published: 10 September 2022
Issue date: February 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 22174105 and 21974104), the National Key Research and Development (R&D) Program of China (No. 2020YFA0908800), and Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.

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