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Nano Research 2023, 16(1): 715-734 https://doi.org/10.1007/s12274-022-4849-6
Review Article | Issue | Published: 16 September 2022

The Yin and Yang of the protein corona on the delivery journey of nanoparticles

Show Author's Information Yi-Feng Wang1,2,§,  Yaxin Zhou3,§,  JiaBei Sun4,  Xiaotong Wang5,  Yaru Jia5,  Kun Ge5,  Yan Yan6,  Kenneth A. Dawson1,6,  Shutao Guo3( ),  Jinchao Zhang5( ),  Xing-Jie Liang1,2,5( )
Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapy, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
China National Institute of Food and Drug Control, Beijing 100061, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
Centre for BioNano Interactions, School of Chemistry, School of Biomolecular and Biomedical Science, University College Dublin, Dublin D04V1W8, Ireland

§ Yi-Feng Wang and Yaxin Zhou contributed equally to this work.

Keywords:
nanoparticles, drug delivery, protein corona, biological identity, bio–nano interaction
Topics:
Drug delivery
Cite this article:
Wang Y-F, Zhou Y, Sun J, et al. The Yin and Yang of the protein corona on the delivery journey of nanoparticles. Nano Research, 2023, 16(1): 715-734. https://doi.org/10.1007/s12274-022-4849-6
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Abstract Full text About this article

Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled manner. However, tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in vivo. These challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological systems. Importantly, once the nanoparticles are injected into the blood, a protein corona will inevitably form on the surface. The protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate results. Thus, it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery efficiency. In this review, we first summarize the fundamental impact of the protein corona on the delivery journey of nanoparticles. Next, we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in vivo. Finally, we highlight what we need to do as a next step towards better understanding and exploitation of the protein corona. We hope these insights into the “Yin and Yang” effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles.


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About this article

The Yin and Yang of the protein corona on the delivery journey of nanoparticles

Show Author's information Yi-Feng Wang1,2,§, Yaxin Zhou3,§, JiaBei Sun4, Xiaotong Wang5, Yaru Jia5, Kun Ge5, Yan Yan6, Kenneth A. Dawson1,6, Shutao Guo3( ), Jinchao Zhang5( ), Xing-Jie Liang1,2,5( )
Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapy, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
China National Institute of Food and Drug Control, Beijing 100061, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
Centre for BioNano Interactions, School of Chemistry, School of Biomolecular and Biomedical Science, University College Dublin, Dublin D04V1W8, Ireland

§ Yi-Feng Wang and Yaxin Zhou contributed equally to this work.

Abstract

Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled manner. However, tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in vivo. These challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological systems. Importantly, once the nanoparticles are injected into the blood, a protein corona will inevitably form on the surface. The protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate results. Thus, it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery efficiency. In this review, we first summarize the fundamental impact of the protein corona on the delivery journey of nanoparticles. Next, we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in vivo. Finally, we highlight what we need to do as a next step towards better understanding and exploitation of the protein corona. We hope these insights into the “Yin and Yang” effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles.

Keywords: nanoparticles, drug delivery, protein corona, biological identity, bio–nano interaction

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Publication history
Copyright
Acknowledgements

Publication history

Received: 28 May 2022
Revised: 30 July 2022
Accepted: 01 August 2022
Published: 16 September 2022
Issue date: January 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 32171386, 51773098, 31971304, 21807023, and 32101126), the Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province (No. B2021201038), and the China Postdoctoral Science Foundation (No. 2021M700954).

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