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Nano Research 2023, 16(1): 951-963 https://doi.org/10.1007/s12274-022-4811-7
Research Article | Issue | Published: 12 September 2022

Implantable versatile oxidized bacterial cellulose membrane for postoperative HNSCC treatment via photothermal-boosted immunotherapy

Show Author's Information Jun-Jie Zhou1,§,  Xiao-Hong Li4,§,  Peng-Yu He4,  Fu-Yu Qi4,  Muhammad Wajid Ullah5,  Shu-Jin Li1,  Yuan-Tong Liu1,  Lin-Lin Bu1,2,3( ),  Guang Yang4( ),  Zhi-Jun Sun1,2 ( )
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Department of Oral Maxillofacial Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and Technology, Wuhan University, Wuhan 430079, China
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China

§ Jun-Jie Zhou and Xiao-Hong Li contributed equally to this work.

Keywords:
immunotherapy, pyroptosis, head and neck squamous cell carcinoma (HNSCC), oxidized bacterial cellulose, postoperative treatment
Topics:
Nano biology
Cite this article:
Zhou J-J, Li X-H, He P-Y, et al. Implantable versatile oxidized bacterial cellulose membrane for postoperative HNSCC treatment via photothermal-boosted immunotherapy. Nano Research, 2023, 16(1): 951-963. https://doi.org/10.1007/s12274-022-4811-7
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Abstract Full text Electronic supplementary material About this article

The recurrence of head and neck squamous cell carcinoma (HNSCC) after surgical resection continues to pose a major challenge to cancer treatment. Advanced HNSCC exhibits a low response rate to immune checkpoint blockade (ICB), while photothermal therapy (PTT) can increase the infiltration of immune cells to make tumors more susceptible to cancer immunotherapy. In this regard, we designed and constructed a novel multifunctional nanocomposite comprised of oxidized bacterial cellulose (OBC), thrombin (TB), and gold nanocages (AuNCs) containing anti-programmed death 1 (PD-1) antibody (αPD-1@AuNCs), which allows the combination of therapies with remarkable postoperative antitumor immunity to control local tumor recurrence. The αPD-1@AuNCs displayed high light-to-heat conversion efficiency and induced pyroptosis under near infrared (NIR) irradiation, which activated a potent antitumor immune response. More importantly, the therapeutic system could induce tumor pyroptosis and enhance antitumor immune response by increasing T-cell infiltration and reducing the immune suppressive cells, when combined with local ICB therapy, which effectively avoided the tumor recurrence in a HNSCC postoperative mice model. Overall, the newly developed multifunctional nanocomposites could be a promising candidate for the treatment of postoperative HNSCC.


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Abstract
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Electronic supplementary material
About this article

Implantable versatile oxidized bacterial cellulose membrane for postoperative HNSCC treatment via photothermal-boosted immunotherapy

Show Author's information Jun-Jie Zhou1,§, Xiao-Hong Li4,§, Peng-Yu He4, Fu-Yu Qi4, Muhammad Wajid Ullah5, Shu-Jin Li1, Yuan-Tong Liu1, Lin-Lin Bu1,2,3( ), Guang Yang4( ), Zhi-Jun Sun1,2 ( )
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Department of Oral Maxillofacial Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and Technology, Wuhan University, Wuhan 430079, China
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China

§ Jun-Jie Zhou and Xiao-Hong Li contributed equally to this work.

Abstract

The recurrence of head and neck squamous cell carcinoma (HNSCC) after surgical resection continues to pose a major challenge to cancer treatment. Advanced HNSCC exhibits a low response rate to immune checkpoint blockade (ICB), while photothermal therapy (PTT) can increase the infiltration of immune cells to make tumors more susceptible to cancer immunotherapy. In this regard, we designed and constructed a novel multifunctional nanocomposite comprised of oxidized bacterial cellulose (OBC), thrombin (TB), and gold nanocages (AuNCs) containing anti-programmed death 1 (PD-1) antibody (αPD-1@AuNCs), which allows the combination of therapies with remarkable postoperative antitumor immunity to control local tumor recurrence. The αPD-1@AuNCs displayed high light-to-heat conversion efficiency and induced pyroptosis under near infrared (NIR) irradiation, which activated a potent antitumor immune response. More importantly, the therapeutic system could induce tumor pyroptosis and enhance antitumor immune response by increasing T-cell infiltration and reducing the immune suppressive cells, when combined with local ICB therapy, which effectively avoided the tumor recurrence in a HNSCC postoperative mice model. Overall, the newly developed multifunctional nanocomposites could be a promising candidate for the treatment of postoperative HNSCC.

Keywords: immunotherapy, pyroptosis, head and neck squamous cell carcinoma (HNSCC), oxidized bacterial cellulose, postoperative treatment

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Publication history
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Acknowledgements

Publication history

Received: 25 May 2022
Revised: 24 July 2022
Accepted: 25 July 2022
Published: 12 September 2022
Issue date: January 2023

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 82072996 (Z. J. S.), 81874131 (Z. J. S.), 81702730 (L. L. B.), and 51973076 (G. Y.)), the Fundamental Research Funds for the Central Universities (No. 2042021kf0216) to Z. J. S., China Postdoctoral Science Foundation (Nos. 2018M630883 and 2019T120688) to L. L. B., and Wuhan Young Medical Talents Training Project to L. L. B.

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