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Research Article

Surface modification of MoS2 nanosheets by single Ni atom for ultrasensitive dopamine detection

Xuejiao Sun1,2Cai Chen2Can Xiong2Congmin Zhang2Xusheng Zheng5Jin Wang3Xiaoping Gao2,3( )Zhen-Qiang Yu1( )Yuen Wu2,4( )
College of Chemistry and Environmental Engineering, Institute of Low-dimensional Materials Genome Initiative, Shenzhen University, Shenzhen 518071, China
School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China
College of Materials Science and Engineering, Shenzhen University, Shenzhen 518071, China
Dalian National Laboratory for Clean Energy, Dalian 116023, China
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
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Graphical Abstract

A pM-level DA sensor based on MoS2 nanosheets surface modified by Ni single atom.

Abstract

Single atom catalysts have been recognized as potential catalysts to fabricate electrochemical biosensors, due to their unexpected catalytic selectivity and activity. Here, we designed and fabricated an ultrasensitive dopamine (DA) sensor based on the flower-like MoS2 embellished with single Ni site catalyst (Ni-MoS2). The limit of detection could achieve 1 pM in phosphate buffer solution (PBS, pH = 7.4), 1 pM in bovine serum (pH = 7.4), and 100 pM in artificial urine (pH = 6.8). The excellent sensing performance was attributed to the Ni single atom axial anchoring on the Mo atom in the MoS2 basal plane with the Ni-S3 structure. Both the experiment and density functional theory (DFT) results certify that this structural feature is more favorable for the adsorption and electron transfer of DA on Ni atoms. The high proportion of Ni active sites on MoS2 basal plane effectively enhanced the intrinsic electronic conductivity and electrochemical activity toward DA. The successful establishment of this sensor gives a new guide to expand the field of single atom catalyst in the application of biosensors.

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Nano Research
Pages 917-924
Cite this article:
Sun X, Chen C, Xiong C, et al. Surface modification of MoS2 nanosheets by single Ni atom for ultrasensitive dopamine detection. Nano Research, 2023, 16(1): 917-924. https://doi.org/10.1007/s12274-022-4802-8
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Received: 27 June 2022
Revised: 20 July 2022
Accepted: 22 July 2022
Published: 15 August 2022
© Tsinghua University Press 2022
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