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As significant biocatalysts, natural enzymes have exhibited a vast range of applications in biocatalytic reactions. However, the “always-on” natural enzyme activity is not beneficial for the regulation of catalytic processes, which limits their bio-applications. Recently, it has been extensively reported that various organic artificial enzymes exhibit prominent absorption and controlled activity under illumination, which not only creates a series of light-responsive catalytic platforms but also plays a key role in biosensing and biomedical research. To provide novel ideas for the design of artificial enzymes, we conduct this review to highlight the recent progress of light-responsive organic artificial enzymes (LOA-Enz). The specific photoresponse mechanism and various bio-applications of LOA-Enz are also presented in detail. Furthermore, the remaining challenges and future perspectives in this field are discussed.
The work was supported by the National Key Research and Development (R&D) Program of China (No. 2020YFA0709900), the National Natural Science Foundation of China (Nos. 62120106002 and 22175089), the Natural Science Foundation of Jiangsu Province (No. BK20200092), the Natural Science Foundation of Ningbo (No. 202003N40448), Research Innovation Plan for Graduate Students in Jiangsu Province (No. SJCX21_0473), and “Taishan scholars” construction special fund of Shandong Province.