Ce and Se co-doped MBG/SA/HLC microgel bone powder for repairing tumor bone defects

The repair and treatment of tumor bone defects is a difficult problem to solve urgently in clinical medicine. After tumor resection, patients are not only faced with a large area of bone defect, but also may have the risk of tumor recurrence, which can easily cause huge physical and mental harm to patients. In this study, we successfully designed and constructed an organic/inorganic composite microgel bone powder (S-H-M_3%Ce/3%Se) based on cerium (Ce) and selenium (Se) elements co-doped mesoporous bioactive glass (M_3%Ce/3%Se), sodium alginate (SA), and recombinant human-like collagen (HLC). The obtained S-H-M_3%Ce/3%Se could inhibit the growth of osteoma cells and promote the growth of normal cells, and effectively promote the repair of defect bone. The integration of the “treatment and repair” organic/inorganic composite microgel bone powder provided a new strategy for the treatment of cancerous bone defects.