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Nano Research 2022, 15(10): 9274-9285 https://doi.org/10.1007/s12274-022-4616-8
Research Article | Issue | Published: 26 July 2022

Green functional carbon dots derived from herbal medicine ameliorate blood–brain barrier permeability following traumatic brain injury

Show Author's Information Weikang Luo1,2,3,§,  Lianglin Zhang1,2,3,§,  Xuexuan Li1,2,3,  Jun Zheng4,  Quan Chen1,2,3,  Zhaoyu Yang1,2,3,  Menghan Cheng1,2,3,  Yao Chen1,2,3,  Yao Wu1,2,3,  Wei Zhang5,  Tao Tang1,2,3,  Yang Wang1,2,3( )
Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China
Laboratory for interdisciplinary science of traditional Chinese medicine, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China

§ Weikang Luo and Lianglin Zhang contributed equally to this work.

Keywords:
carbon dots, traumatic brain injury, blood–brain barrier, herbal medicine, claudin 5
Topics:
Amorphous carbon Biomaterials Brain Medical nanotechnologyNanobiotechnology
Cite this article:
Luo W, Zhang L, Li X, et al. Green functional carbon dots derived from herbal medicine ameliorate blood–brain barrier permeability following traumatic brain injury. Nano Research, 2022, 15(10): 9274-9285. https://doi.org/10.1007/s12274-022-4616-8
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Abstract Full text Electronic supplementary material About this article

To repair the blood–brain barrier (BBB) after traumatic brain injury (TBI) remains a multidisciplinary challenge. No first-line drugs are available. Here, we reported a novel and non-toxic functional negative-charged carbon dots (CDs) generated from green Semen pruni persicae and Carthamus tinctorius L. (TH-CDs) through a hydrothermal synthesis without any organic solvent. The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs. TH-CDs could improve the neurological function, brain edema, neuronal damage, and the BBB permeability by tail vein injection of mice models without systemic toxicity. Furthermore, higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration, which may be due to the electrostatic interaction between TH-CDs and claudin 5. Our study highlights an inexpensive, green, non-toxic, and intravenous functional TH-CD, which represents a potential TBI treatment strategy.


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Abstract
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Electronic supplementary material
About this article

Green functional carbon dots derived from herbal medicine ameliorate blood–brain barrier permeability following traumatic brain injury

Show Author's information Weikang Luo1,2,3,§, Lianglin Zhang1,2,3,§, Xuexuan Li1,2,3, Jun Zheng4, Quan Chen1,2,3, Zhaoyu Yang1,2,3, Menghan Cheng1,2,3, Yao Chen1,2,3, Yao Wu1,2,3, Wei Zhang5, Tao Tang1,2,3, Yang Wang1,2,3( )
Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China
Laboratory for interdisciplinary science of traditional Chinese medicine, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China

§ Weikang Luo and Lianglin Zhang contributed equally to this work.

Abstract

To repair the blood–brain barrier (BBB) after traumatic brain injury (TBI) remains a multidisciplinary challenge. No first-line drugs are available. Here, we reported a novel and non-toxic functional negative-charged carbon dots (CDs) generated from green Semen pruni persicae and Carthamus tinctorius L. (TH-CDs) through a hydrothermal synthesis without any organic solvent. The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs. TH-CDs could improve the neurological function, brain edema, neuronal damage, and the BBB permeability by tail vein injection of mice models without systemic toxicity. Furthermore, higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration, which may be due to the electrostatic interaction between TH-CDs and claudin 5. Our study highlights an inexpensive, green, non-toxic, and intravenous functional TH-CD, which represents a potential TBI treatment strategy.

Keywords: carbon dots, traumatic brain injury, blood–brain barrier, herbal medicine, claudin 5

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Publication history
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Acknowledgements

Publication history

Received: 06 April 2022
Revised: 02 June 2022
Accepted: 03 June 2022
Published: 26 July 2022
Issue date: October 2022

Copyright

© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81973665), the Science and Technology Innovation Program of Hunan Province (No. 2021RC3030), the Fundamental Research Funds for the Central Universities of Central South University (No. 2021zzts1028), and the Innovation-Driven Project of Central South University (No. 2020CX047).

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