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Although nanozyme has become an emerging area of research attracting extensive attention recently, the activity and specificity of currently reported nanozymes are generally lower than those of natural enzymes. Developing highly active and specific nanozymes is therefore extremely necessary and also remains a great challenge. Superoxide dismutase (SOD) catalyzes the disproportionation of cytotoxic O2·− into hydrogen peroxide and oxygen, and plays an important role in reducing human oxidative stress. In this work, we prepare Cu single-atom catalysts (Cu/GO SACs, GO = graphene oxide) through a simple and low-cost strategy at room temperature using Cu foam and graphene oxide. Cu/GO SACs can maintain excellent catalytic activity under harsh environment. Compared with the natural enzyme, SOD-like Cu/GO SAC nanozyme has higher catalytic activity and meanwhile, it does not possess the common properties of other mimic enzymes often existing in nanomaterials. Based on the excellent SOD-like enzyme activity of Cu/GO SACs, it successfully eliminates the active oxygen in cigarette smoke. This work not only provides a new idea for the design and synthesis of nanozymes with excellent SOD mimetic properties, but also is promising in the treatment of lung injury and inflammatory diseases related to free radical production.

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Publication history

Received: 23 March 2022
Revised: 30 April 2022
Accepted: 17 May 2022
Published: 26 July 2022
Issue date: October 2022

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© Tsinghua University Press 2022

Acknowledgements

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 22074095), Beijing Municipal Natural Science Foundation (No. 2222005) and High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-Year Plan (No. CIT&TCD20190330).

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Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

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